Polyamine Homeostasis in Development and Disease

Polycationic polyamines are present in nearly all living organisms and are essential for mammalian cell growth and survival, and for development. These positively charged molecules are involved in a variety of essential biological processes, yet their underlying mechanisms of action are not fully un...

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Bibliographic Details
Published in:Medical sciences (Basel) 2021-05, Vol.9 (2), p.28
Main Authors: Nakanishi, Shima, Cleveland, John L
Format: Article
Language:English
Subjects:
Age
Aging
Autophagy
Biosynthesis
Cancer
Cardiomyocytes
Cell Proliferation
development
Enzymes
Homeostasis
Humans
Insects
Mammals
Metabolism
Nematodes
Neoplasms - drug therapy
Neuroblastoma
Polyamines
Polyamines - metabolism
Review
Yeast
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Summary:Polycationic polyamines are present in nearly all living organisms and are essential for mammalian cell growth and survival, and for development. These positively charged molecules are involved in a variety of essential biological processes, yet their underlying mechanisms of action are not fully understood. Several studies have shown both beneficial and detrimental effects of polyamines on human health. In cancer, polyamine metabolism is frequently dysregulated, and elevated polyamines have been shown to promote tumor growth and progression, suggesting that targeting polyamines is an attractive strategy for therapeutic intervention. In contrast, polyamines have also been shown to play critical roles in lifespan, cardiac health and in the development and function of the brain. Accordingly, a detailed understanding of mechanisms that control polyamine homeostasis in human health and disease is needed to develop safe and effective strategies for polyamine-targeted therapy.
ISSN:2076-3271
2076-3271
DOI:10.3390/medsci9020028