Interaction between the stage of chronic kidney disease and diabetes mellitus as factors associated with mortality in chronic kidney disease patients: An external cohort study

• Published in: Nefrología 2022-09, Vol.42 (5), p.540-548
• Main Authors: Villegas Sierra, Laura E., Buriticá Agudelo, Melisa, Yepes Delgado, Carlos Enrique, Montoya Jaramillo, Yanett Marcela, Jaimes Barragan, Fabián
• Format: Article
• Language: English
• Subjects: Cardiovascular risk factors; Chronic kidney disease; Cohort Studies; Diabetes mellitus; Diabetes Mellitus - epidemiology; Diabetic Nephropathies - epidemiology; Enfermedad renal crónica; Factores de riesgo cardiovascular; Humans; Mortalidad; Mortality; Proportional Hazards Models; Renal Insufficiency, Chronic; Risk Factors
• ISSN: 2013-2514; 2013-2514
• DOI: 10.1016/j.nefroe.2021.04.011

Diabetic kidney disease is the main cause of chronic kidney disease (CKD) worldwide. Both CKD and diabetes mellitus (DMT2) are important risk factors for mortality. However, it is still unknown if the risk of death is modified by the simultaneous presence of these diseases. To evaluate the presence of an interaction between DMT2 and CKD for mortality in a representative population of a Latin American country. It is an analytical cohort study of patients with CKD, who were followed for 4 years (between 2004 and 2009). We calculated the incidence rate, progression, survival (using Kaplan–Meier curves), interaction (on the additive and multiplicative scales) and impact of the different stages of CKD in patients with and without DMT2 (using a cox proportional hazards model). In this population of 5663 individuals, both DMT2 and CKD are risk factors for mortality (p