Intermittent oral levetiracetam reduced recurrence of febrile seizure accompanied with epileptiform discharge: a pilot study

In previous study, we have found intermittent oral levetiracetam (LEV) can effectively prevent recurrence of febrile seizure (FS). This study aimed to analyze the effects of the preventive on the patients with frequent FS accompanied with epileptiform discharge. Patients with frequent FS were assign...

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Bibliographic Details
Published in:Italian journal of pediatrics 2018-06, Vol.44 (1), p.70-70, Article 70
Main Authors: Hu, Lin-Yan, Shi, Xiu-Yu, Li, Hui, Zhang, Meng-Na, Ma, Shu-Fang, Zou, Li-Ping
Format: Article
Language:English
Subjects:
Administration, Oral
Ambulatory Care
Anticonvulsants - administration & dosage
Caregivers
Child, Preschool
Children
Children & youth
Clinical trials
Cohort Studies
Comorbidity
Convulsions & seizures
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug dosages
EEG
Electroencephalogram
Electroencephalography - methods
Epilepsy
Epilepsy - diagnostic imaging
Epilepsy - drug therapy
Epilepsy - epidemiology
Epileptiform discharge
Etiracetam
Febrile seizure
Female
Fever
Humans
Infant
Levetiracetam
Male
Oral administration
Pediatrics
Pilot Projects
Piracetam - administration & dosage
Piracetam - analogs & derivatives
Prognosis
Recurrence
Retrospective Studies
Seizures
Seizures, Febrile - diagnostic imaging
Seizures, Febrile - drug therapy
Seizures, Febrile - epidemiology
Severity of Illness Index
Sleep
Treatment Outcome
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Summary:In previous study, we have found intermittent oral levetiracetam (LEV) can effectively prevent recurrence of febrile seizure (FS). This study aimed to analyze the effects of the preventive on the patients with frequent FS accompanied with epileptiform discharge. Patients with frequent FS were assigned to undergo Electroencephalogram (EEG). At the onset of fever, the patients who presented epileptiform discharge were orally administered with LEV with a dose of 15-30 mg/kg per day twice daily for 1 week, thereafter, the dosage was gradually reduced until totally discontinued in the second week. The seizure frequency associated with febrile events and FS recurrence rate during a 48-week follow-up were analyzed. among the 19 patients presented epileptiform discharge on EEG, 31.58% (6 of 19) had complex FS, 68.42% (13 of 19) had simple FS. Up to 57.89% (11 of 19) had a family history of seizure disorder and 36.84% (7 of 19) had a family history of FS in first-degree relatives. 42.11% (8 of 19) happened the first FS episode at the age 
ISSN:1824-7288
1720-8424
1824-7288
DOI:10.1186/s13052-018-0507-8