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Intermittent oral levetiracetam reduced recurrence of febrile seizure accompanied with epileptiform discharge: a pilot study
In previous study, we have found intermittent oral levetiracetam (LEV) can effectively prevent recurrence of febrile seizure (FS). This study aimed to analyze the effects of the preventive on the patients with frequent FS accompanied with epileptiform discharge. Patients with frequent FS were assign...
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| Published in: | Italian journal of pediatrics 2018-06, Vol.44 (1), p.70-70, Article 70 |
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| creator | Hu, Lin-Yan Shi, Xiu-Yu Li, Hui Zhang, Meng-Na Ma, Shu-Fang Zou, Li-Ping |
| description | In previous study, we have found intermittent oral levetiracetam (LEV) can effectively prevent recurrence of febrile seizure (FS). This study aimed to analyze the effects of the preventive on the patients with frequent FS accompanied with epileptiform discharge.
Patients with frequent FS were assigned to undergo Electroencephalogram (EEG). At the onset of fever, the patients who presented epileptiform discharge were orally administered with LEV with a dose of 15-30 mg/kg per day twice daily for 1 week, thereafter, the dosage was gradually reduced until totally discontinued in the second week. The seizure frequency associated with febrile events and FS recurrence rate during a 48-week follow-up were analyzed.
among the 19 patients presented epileptiform discharge on EEG, 31.58% (6 of 19) had complex FS, 68.42% (13 of 19) had simple FS. Up to 57.89% (11 of 19) had a family history of seizure disorder and 36.84% (7 of 19) had a family history of FS in first-degree relatives. 42.11% (8 of 19) happened the first FS episode at the age |
| doi_str_mv | 10.1186/s13052-018-0507-8 |
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Patients with frequent FS were assigned to undergo Electroencephalogram (EEG). At the onset of fever, the patients who presented epileptiform discharge were orally administered with LEV with a dose of 15-30 mg/kg per day twice daily for 1 week, thereafter, the dosage was gradually reduced until totally discontinued in the second week. The seizure frequency associated with febrile events and FS recurrence rate during a 48-week follow-up were analyzed.
among the 19 patients presented epileptiform discharge on EEG, 31.58% (6 of 19) had complex FS, 68.42% (13 of 19) had simple FS. Up to 57.89% (11 of 19) had a family history of seizure disorder and 36.84% (7 of 19) had a family history of FS in first-degree relatives. 42.11% (8 of 19) happened the first FS episode at the age < 18 months. 36.84% (7/19) presented generalized spikes, 63.16% (12/19) showed focal spikes. During the 48-week follow-up period, the patients experienced 26 febrile episodes, none of them presented seizure recurrence.
Intermittent oral LEV can prevent the seizure recurrence of FS accompanied with epileptiform discharge in 48-week. However, further randomized controlled trials should be conducted.
ChiCTR-IPR-15007241 ; Registered 1 January 2014 - Retrospectively registered.</description><identifier>ISSN: 1824-7288</identifier><identifier>ISSN: 1720-8424</identifier><identifier>EISSN: 1824-7288</identifier><identifier>DOI: 10.1186/s13052-018-0507-8</identifier><identifier>PMID: 29907116</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Administration, Oral ; Ambulatory Care ; Anticonvulsants - administration & dosage ; Caregivers ; Child, Preschool ; Children ; Children & youth ; Clinical trials ; Cohort Studies ; Comorbidity ; Convulsions & seizures ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug dosages ; EEG ; Electroencephalogram ; Electroencephalography - methods ; Epilepsy ; Epilepsy - diagnostic imaging ; Epilepsy - drug therapy ; Epilepsy - epidemiology ; Epileptiform discharge ; Etiracetam ; Febrile seizure ; Female ; Fever ; Humans ; Infant ; Levetiracetam ; Male ; Oral administration ; Pediatrics ; Pilot Projects ; Piracetam - administration & dosage ; Piracetam - analogs & derivatives ; Prognosis ; Recurrence ; Retrospective Studies ; Seizures ; Seizures, Febrile - diagnostic imaging ; Seizures, Febrile - drug therapy ; Seizures, Febrile - epidemiology ; Severity of Illness Index ; Sleep ; Treatment Outcome</subject><ispartof>Italian journal of pediatrics, 2018-06, Vol.44 (1), p.70-70, Article 70</ispartof><rights>Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s). 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c560t-b1b123a5a9fb8c766f1ec68243a361748be1db4017e2cb52084c4ceda384e5483</citedby><cites>FETCH-LOGICAL-c560t-b1b123a5a9fb8c766f1ec68243a361748be1db4017e2cb52084c4ceda384e5483</cites><orcidid>0000-0001-7233-9378</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003147/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2056622764?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29907116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hu, Lin-Yan</creatorcontrib><creatorcontrib>Shi, Xiu-Yu</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>Zhang, Meng-Na</creatorcontrib><creatorcontrib>Ma, Shu-Fang</creatorcontrib><creatorcontrib>Zou, Li-Ping</creatorcontrib><title>Intermittent oral levetiracetam reduced recurrence of febrile seizure accompanied with epileptiform discharge: a pilot study</title><title>Italian journal of pediatrics</title><addtitle>Ital J Pediatr</addtitle><description>In previous study, we have found intermittent oral levetiracetam (LEV) can effectively prevent recurrence of febrile seizure (FS). This study aimed to analyze the effects of the preventive on the patients with frequent FS accompanied with epileptiform discharge.
Patients with frequent FS were assigned to undergo Electroencephalogram (EEG). At the onset of fever, the patients who presented epileptiform discharge were orally administered with LEV with a dose of 15-30 mg/kg per day twice daily for 1 week, thereafter, the dosage was gradually reduced until totally discontinued in the second week. The seizure frequency associated with febrile events and FS recurrence rate during a 48-week follow-up were analyzed.
among the 19 patients presented epileptiform discharge on EEG, 31.58% (6 of 19) had complex FS, 68.42% (13 of 19) had simple FS. Up to 57.89% (11 of 19) had a family history of seizure disorder and 36.84% (7 of 19) had a family history of FS in first-degree relatives. 42.11% (8 of 19) happened the first FS episode at the age < 18 months. 36.84% (7/19) presented generalized spikes, 63.16% (12/19) showed focal spikes. During the 48-week follow-up period, the patients experienced 26 febrile episodes, none of them presented seizure recurrence.
Intermittent oral LEV can prevent the seizure recurrence of FS accompanied with epileptiform discharge in 48-week. However, further randomized controlled trials should be conducted.
ChiCTR-IPR-15007241 ; Registered 1 January 2014 - Retrospectively registered.</description><subject>Administration, Oral</subject><subject>Ambulatory Care</subject><subject>Anticonvulsants - administration & dosage</subject><subject>Caregivers</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>Clinical trials</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Convulsions & seizures</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Drug dosages</subject><subject>EEG</subject><subject>Electroencephalogram</subject><subject>Electroencephalography - methods</subject><subject>Epilepsy</subject><subject>Epilepsy - diagnostic imaging</subject><subject>Epilepsy - drug therapy</subject><subject>Epilepsy - epidemiology</subject><subject>Epileptiform discharge</subject><subject>Etiracetam</subject><subject>Febrile seizure</subject><subject>Female</subject><subject>Fever</subject><subject>Humans</subject><subject>Infant</subject><subject>Levetiracetam</subject><subject>Male</subject><subject>Oral administration</subject><subject>Pediatrics</subject><subject>Pilot Projects</subject><subject>Piracetam - administration & dosage</subject><subject>Piracetam - analogs & derivatives</subject><subject>Prognosis</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><subject>Seizures</subject><subject>Seizures, Febrile - diagnostic imaging</subject><subject>Seizures, Febrile - drug therapy</subject><subject>Seizures, Febrile - epidemiology</subject><subject>Severity of Illness Index</subject><subject>Sleep</subject><subject>Treatment Outcome</subject><issn>1824-7288</issn><issn>1720-8424</issn><issn>1824-7288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkk1v1DAQhiMEoqXwA7ggS1y4BPwVx-GAhCo-VqrEBc7WxBnvepXEwXaKivrj6-2WquU0I8_rRzOv3qp6zeh7xrT6kJigDa8p0zVtaFvrJ9Up01zWLdf66YP-pHqR0p5SwRvFnlcnvOtoy5g6ra43c8Y4-ZxxziREGMmIl5h9BIsZJhJxWC0Opdo1RpwtkuCIwz76EUlC_3eNSMDaMC0w-6L84_OO4FLGS_YuxIkMPtkdxC1-JEDKIGSS8jpcvayeORgTvrqrZ9Wvr19-nn-vL35825x_vqhto2iue9YzLqCBzvXatko5hlaV2wQIxVqpe2RDLylrkdu-4VRLK8vOILTERmpxVm2O3CHA3izRTxCvTABvbh9C3BqI2dsRDcUGJGuhkKgceNdzBs6iBis754QsrE9H1rL2Ew622FZMewR9PJn9zmzDpVHFfibbAnh3B4jh94opm6nYg-MIM4Y1GU4bJbqGSlWkb_-T7sMa52LVrUpx3qrDRuyosjGkFNHdL8OoOeTEHHNiSk7MISfm4Mibh1fc__gXDHEDoLe8Iw</recordid><startdate>20180615</startdate><enddate>20180615</enddate><creator>Hu, Lin-Yan</creator><creator>Shi, Xiu-Yu</creator><creator>Li, Hui</creator><creator>Zhang, Meng-Na</creator><creator>Ma, Shu-Fang</creator><creator>Zou, Li-Ping</creator><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-7233-9378</orcidid></search><sort><creationdate>20180615</creationdate><title>Intermittent oral levetiracetam reduced recurrence of febrile seizure accompanied with epileptiform discharge: a pilot study</title><author>Hu, Lin-Yan ; Shi, Xiu-Yu ; Li, Hui ; Zhang, Meng-Na ; Ma, Shu-Fang ; Zou, Li-Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c560t-b1b123a5a9fb8c766f1ec68243a361748be1db4017e2cb52084c4ceda384e5483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Administration, Oral</topic><topic>Ambulatory Care</topic><topic>Anticonvulsants - administration & dosage</topic><topic>Caregivers</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Children & youth</topic><topic>Clinical trials</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Convulsions & seizures</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Drug dosages</topic><topic>EEG</topic><topic>Electroencephalogram</topic><topic>Electroencephalography - methods</topic><topic>Epilepsy</topic><topic>Epilepsy - diagnostic imaging</topic><topic>Epilepsy - drug therapy</topic><topic>Epilepsy - epidemiology</topic><topic>Epileptiform discharge</topic><topic>Etiracetam</topic><topic>Febrile seizure</topic><topic>Female</topic><topic>Fever</topic><topic>Humans</topic><topic>Infant</topic><topic>Levetiracetam</topic><topic>Male</topic><topic>Oral administration</topic><topic>Pediatrics</topic><topic>Pilot Projects</topic><topic>Piracetam - administration & dosage</topic><topic>Piracetam - analogs & derivatives</topic><topic>Prognosis</topic><topic>Recurrence</topic><topic>Retrospective Studies</topic><topic>Seizures</topic><topic>Seizures, Febrile - diagnostic imaging</topic><topic>Seizures, Febrile - drug therapy</topic><topic>Seizures, Febrile - epidemiology</topic><topic>Severity of Illness Index</topic><topic>Sleep</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Lin-Yan</creatorcontrib><creatorcontrib>Shi, Xiu-Yu</creatorcontrib><creatorcontrib>Li, Hui</creatorcontrib><creatorcontrib>Zhang, Meng-Na</creatorcontrib><creatorcontrib>Ma, Shu-Fang</creatorcontrib><creatorcontrib>Zou, Li-Ping</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Italian journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Lin-Yan</au><au>Shi, Xiu-Yu</au><au>Li, Hui</au><au>Zhang, Meng-Na</au><au>Ma, Shu-Fang</au><au>Zou, Li-Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intermittent oral levetiracetam reduced recurrence of febrile seizure accompanied with epileptiform discharge: a pilot study</atitle><jtitle>Italian journal of pediatrics</jtitle><addtitle>Ital J Pediatr</addtitle><date>2018-06-15</date><risdate>2018</risdate><volume>44</volume><issue>1</issue><spage>70</spage><epage>70</epage><pages>70-70</pages><artnum>70</artnum><issn>1824-7288</issn><issn>1720-8424</issn><eissn>1824-7288</eissn><abstract>In previous study, we have found intermittent oral levetiracetam (LEV) can effectively prevent recurrence of febrile seizure (FS). This study aimed to analyze the effects of the preventive on the patients with frequent FS accompanied with epileptiform discharge.
Patients with frequent FS were assigned to undergo Electroencephalogram (EEG). At the onset of fever, the patients who presented epileptiform discharge were orally administered with LEV with a dose of 15-30 mg/kg per day twice daily for 1 week, thereafter, the dosage was gradually reduced until totally discontinued in the second week. The seizure frequency associated with febrile events and FS recurrence rate during a 48-week follow-up were analyzed.
among the 19 patients presented epileptiform discharge on EEG, 31.58% (6 of 19) had complex FS, 68.42% (13 of 19) had simple FS. Up to 57.89% (11 of 19) had a family history of seizure disorder and 36.84% (7 of 19) had a family history of FS in first-degree relatives. 42.11% (8 of 19) happened the first FS episode at the age < 18 months. 36.84% (7/19) presented generalized spikes, 63.16% (12/19) showed focal spikes. During the 48-week follow-up period, the patients experienced 26 febrile episodes, none of them presented seizure recurrence.
Intermittent oral LEV can prevent the seizure recurrence of FS accompanied with epileptiform discharge in 48-week. However, further randomized controlled trials should be conducted.
ChiCTR-IPR-15007241 ; Registered 1 January 2014 - Retrospectively registered.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>29907116</pmid><doi>10.1186/s13052-018-0507-8</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-7233-9378</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Italian journal of pediatrics, 2018-06, Vol.44 (1), p.70-70, Article 70 |
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| subjects | Administration, Oral Ambulatory Care Anticonvulsants - administration & dosage Caregivers Child, Preschool Children Children & youth Clinical trials Cohort Studies Comorbidity Convulsions & seizures Dose-Response Relationship, Drug Drug Administration Schedule Drug dosages EEG Electroencephalogram Electroencephalography - methods Epilepsy Epilepsy - diagnostic imaging Epilepsy - drug therapy Epilepsy - epidemiology Epileptiform discharge Etiracetam Febrile seizure Female Fever Humans Infant Levetiracetam Male Oral administration Pediatrics Pilot Projects Piracetam - administration & dosage Piracetam - analogs & derivatives Prognosis Recurrence Retrospective Studies Seizures Seizures, Febrile - diagnostic imaging Seizures, Febrile - drug therapy Seizures, Febrile - epidemiology Severity of Illness Index Sleep Treatment Outcome |
| title | Intermittent oral levetiracetam reduced recurrence of febrile seizure accompanied with epileptiform discharge: a pilot study |
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