Does liver cirrhosis affect the surgical outcome of primary colorectal cancer surgery? A meta-analysis

Purpose The purpose of this meta-analysis was to evaluate the effect of liver cirrhosis (LC) on the short-term and long-term surgical outcomes of colorectal cancer (CRC). Methods The PubMed, Embase, and Cochrane Library databases were searched from inception to March 23, 2021. The Newcastle-Ottawa S...

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Bibliographic Details
Published in:World journal of surgical oncology 2021-06, Vol.19 (1), p.1-167, Article 167
Main Authors: Cheng, Yu-Xi, Tao, Wei, Zhang, Hua, Peng, Dong, Wei, Zheng-Qiang
Format: Article
Language:English
Subjects:
Bias
Cancer
Care and treatment
Cirrhosis
Colorectal cancer
Colorectal carcinoma
Comorbidity
Complications
Complications and side effects
Data analysis
Disease
Liver
Liver cirrhosis
Meta-analysis
Mortality
Patient outcomes
Quality assessment
Surgery
Surgical outcome
Surgical outcomes
Survival
Tumors
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Summary:Purpose The purpose of this meta-analysis was to evaluate the effect of liver cirrhosis (LC) on the short-term and long-term surgical outcomes of colorectal cancer (CRC). Methods The PubMed, Embase, and Cochrane Library databases were searched from inception to March 23, 2021. The Newcastle-Ottawa Scale (NOS) was used to assess the quality of enrolled studies, and RevMan 5.3 was used for data analysis in this meta-analysis. The registration ID of this current meta-analysis on PROSPERO is CRD42021238042. Results In total, five studies with 2485 patients were included in this meta-analysis. For the baseline information, no significant differences in age, sex, tumor location, or tumor T staging were noted. Regarding short-term outcomes, the cirrhotic group had more major complications (OR=5.15, 95% CI=1.62 to 16.37, p=0.005), a higher re-operation rate (OR=2.04, 95% CI=1.07 to 3.88, p=0.03), and a higher short-term mortality rate (OR=2.85, 95% CI=1.93 to 4.20, p
ISSN:1477-7819
1477-7819
DOI:10.1186/s12957-021-02267-6