Cutaneous metastasis of cecum cancer with MSI-high and BRAFV600E mutation: a case report

Background Cutaneous metastases of colorectal cancer (CRC) are rare, occurring in 0.7% to 5% of cancer patients. Furthermore, the molecular subtypes of cutaneous metastasis of CRC are unclear. Here, we present a rare case of cutaneous metastasis of high-frequency microsatellite instability (MSI-high...

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Published in:Surgical case reports 2021-08, Vol.7 (1), p.185-185, Article 185
Main Authors: Yunoki, Kosuke, Yano, Takuya, Yoshimitsu, Masanori, Oshita, Ko, Kubota, Tetsushi, Ishida, Michihiro, Satoh, Daisuke, Choda, Yasuhiro, Nakano, Kanyu, Shirakawa, Yasuhiro, Matsukawa, Hiroyoshi, Idani, Hitoshi, Shiozaki, Shigehiro, Okajima, Masazumi
Format: Article
Language:English
Subjects:
BRAFV600E
Cancer
Case Report
Case reports
Colon cancer
Colorectal cancer
Colorectal surgery
Cutaneous metastasis
Medicine
Medicine & Public Health
Metastasis
Microsatellite instability
Surgery
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Summary:Background Cutaneous metastases of colorectal cancer (CRC) are rare, occurring in 0.7% to 5% of cancer patients. Furthermore, the molecular subtypes of cutaneous metastasis of CRC are unclear. Here, we present a rare case of cutaneous metastasis of high-frequency microsatellite instability (MSI-high)/BRAFV600E-mutant cecum cancer. Case presentation A 77-year-old woman presented at the outpatient clinic with a subcutaneous mass on her left back. An excisional biopsy was performed and metastatic cutaneous adenocarcinoma was diagnosed. A computed tomography scan of the thorax and abdomen showed thickening of the cecum wall, the presence of pericolic lymph nodes, multiple masses in the liver, and a single nodule in the right lung. Right colectomy with D2 lymphadenectomy and functional end-to-end anastomosis was performed because of the almost-complete intestinal obstruction. The expression of KRAS wild type, BRAFV600E mutation, and MSI-high was detected in the cecum cancer using molecular pathological examination. She received chemotherapy with XELOX + BEV regimen (capecitabine + oxaliplatin + bevacizumab). After four administrations, a computed tomography scan showed reduction of distant metastases, which suggested partial response. Conclusions We encountered a rare case of cutaneous metastasis of MSI-high and BRAFV600E-mutant cecum cancer. In the future, it will be necessary to accumulate more cases to identify clinical features and more effective treatments for CRCs with cutaneous metastasis.
ISSN:2198-7793
2198-7793
DOI:10.1186/s40792-021-01265-w