Pituitary adenoma associated with xanthogranuloma

Xanthogranuloma (XG) of the sellar region is a non-neoplastic inflammatory lesion characterized histologically by recent and remote hemorrhage, necrotic debris, fibrosis, chronic inflammation, and cholesterol clefts with associated foreign-body giant cells. The inflammatory lesion was recognized by...

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Bibliographic Details
Published in:Radiology case reports 2023-06, Vol.18 (6), p.2078-2080
Main Authors: Armao, Diane, Bouldin, Thomas W., Hartman, Terry S., Thorp, Brian D., Jewells, Valerie
Format: Article
Language:English
Subjects:
Case Report
Pituitary adenoma
Sellar xanthogranuloma
Subclinical pituitary apoplexy
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Description
Summary:Xanthogranuloma (XG) of the sellar region is a non-neoplastic inflammatory lesion characterized histologically by recent and remote hemorrhage, necrotic debris, fibrosis, chronic inflammation, and cholesterol clefts with associated foreign-body giant cells. The inflammatory lesion was recognized by the World Health Organization in 2000. XG of the sellar region is rare. Cases of pituitary adenoma (PA) with an associated XG (PA/XG) are extremely rare, with a total of 16 cases in the literature. PA/XG lacks specific clinical and radiologic signs, making pre-operative diagnosis challenging. Herein, we report a case of PA/XG, describe the radiologic and pathologic findings, and discuss the role of so-called silent or “subclinical pituitary apoplexy” in the possible histogenesis of PA/XGs.
ISSN:1930-0433
1930-0433
DOI:10.1016/j.radcr.2023.03.015