Rapid Effect of Benralizumab for Hypereosinophilia in a Case of Severe Asthma with Eosinophilic Chronic Rhinosinusitis

A 56-year-old man with severe asthma underwent bronchial thermoplasty (BT). However, his asthma exacerbated and hypereosinophilia developed 2 months later, thus necessitating oral corticosteroid (OCS) therapy. Six months after BT, a diagnosis of severe asthma with eosinophilic chronic rhinosinusitis...

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Bibliographic Details
Published in:Medicina (Kaunas, Lithuania) Lithuania), 2019-07, Vol.55 (7), p.336
Main Authors: Tsurumaki, Hiroaki, Matsuyama, Toshiyuki, Ezawa, Kazuma, Koga, Yasuhiko, Yatomi, Masakiyo, Aoki-Saito, Haruka, Chikamatsu, Kazuaki, Hisada, Takeshi
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal, Humanized - pharmacology
Antibodies, Monoclonal, Humanized - therapeutic use
Asthma - complications
Asthma - drug therapy
benralizumab
bronchial thermoplasty
Bronchial Thermoplasty - methods
Case Report
Disease Progression
Eosinophilia - complications
Eosinophilia - drug therapy
eosinophilic chronic rhinosinusitis
Humans
hypereosinophilia
Male
Middle Aged
severe asthma
Sinusitis - complications
Sinusitis - drug therapy
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Summary:A 56-year-old man with severe asthma underwent bronchial thermoplasty (BT). However, his asthma exacerbated and hypereosinophilia developed 2 months later, thus necessitating oral corticosteroid (OCS) therapy. Six months after BT, a diagnosis of severe asthma with eosinophilic chronic rhinosinusitis (ECRS) was made and benralizumab treatment was initiated; the blood eosinophil count subsequently decreased and lung function improved, thereby permitting OCS dose tapering. Surprisingly, benralizumab both reduced nasal polyps and ameliorated ECRS. Thus, benralizumab may be a useful drug for the rapid treatment of severe asthma with ECRS, especially in patients with hypereosinophilia.
ISSN:1648-9144
1010-660X
1648-9144
1010-660X
DOI:10.3390/medicina55070336