LncRNA-MALAT1: A Key Participant in the Occurrence and Development of Cancer

LncRNAs are a group of non-coding RNA transcripts with lengths of over 200 nucleotides and can interact with DNA, RNA, and proteins to regulate gene expression of malignant tumors in human tissues. LncRNAs participate in vital processes, such as chromosomal nuclear transport in the cancerous site of...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-02, Vol.28 (5), p.2126
Main Authors: Hao, Longhui, Wu, Wenzheng, Xu, Yankun, Chen, Yufan, Meng, Chengzhen, Yun, Jingyi, Wang, Xiaoyu
Format: Article
Language:English
Subjects:
action pathway
Apoptosis
Cancer
Cell differentiation
Cell growth
Cell Line, Tumor
Chromosomes
Cytoplasm
Development and progression
DNA methylation
Drug development
Epigenetics
Gene expression
Genes
Genomes
Health aspects
Homeostasis
Human tissues
Humans
Immune system
lncRNA-MALAT1
long non-coding RNA
Lung cancer
mechanism
Metastases
Metastasis
MicroRNAs
Neoplasms - pathology
Non-coding RNA
Nuclear transport
Nucleotides
Pancreatic cancer
Physiology
Proteins
Proto-oncogenes
Review
RNA
RNA, Long Noncoding - genetics
Signal transduction
Therapeutic targets
Transcription factors
Tumors
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Summary:LncRNAs are a group of non-coding RNA transcripts with lengths of over 200 nucleotides and can interact with DNA, RNA, and proteins to regulate gene expression of malignant tumors in human tissues. LncRNAs participate in vital processes, such as chromosomal nuclear transport in the cancerous site of human tissue, activation, and the regulation of proto-oncogenes, the differentiation of immune cells, and the regulation of the cellular immune system. The lncRNA metastasis-associated lung cancer transcript 1 (MALAT1) is reportedly involved in the occurrence and development of many cancers and serves as a biomarker and therapeutic target. These findings highlight its promising role in cancer treatment. In this article, we comprehensively summarized the structure and functions of lncRNA, notably the discoveries of lncRNA-MALAT1 in different cancers, the action mechanisms, and the ongoing research on new drug development. We believe our review would serve as a basis for further research on the pathological mechanism of lncRNA-MALAT1 in cancer and provide evidence and novel insights into its application in clinical diagnoses and treatments.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28052126