Applications and therapeutic mechanisms of action of mesenchymal stem cells in radiation-induced lung injury

Radiation-induced lung injury (RILI) is one of the most common complications associated with radiotherapy, characterized by early-stage radiation pneumonia and subsequent radiation pulmonary fibrosis. However, effective therapeutic strategies for RILI are currently lacking. Recently, an increasing n...

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Bibliographic Details
Published in:Stem cell research & therapy 2021-03, Vol.12 (1), p.212-212, Article 212
Main Authors: Niu, Shiying, Zhang, Yueying
Format: Article
Language:English
Subjects:
Apoptosis
Bone marrow
Complications and side effects
Cytokines
Deoxyribonucleic acid
DNA
Fibroblasts
Fibrosis
Gene expression
Growth factors
Immune system
Inflammation
Lung diseases
Mesenchymal stem cell
Mesenchymal stem cells
Mitochondrial DNA
Neutrophils
Pathogenesis
Pulmonary fibrosis
Radiation
Radiation therapy
Radiation-induced lung injury
Radiotherapy
Reactive oxygen species
Review
Signal transduction
Stem cell research
Stem cell therapy
Stem cells
Technology application
Transplantation
Tumor necrosis factor-TNF
Umbilical cord
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Summary:Radiation-induced lung injury (RILI) is one of the most common complications associated with radiotherapy, characterized by early-stage radiation pneumonia and subsequent radiation pulmonary fibrosis. However, effective therapeutic strategies for RILI are currently lacking. Recently, an increasing number of studies reported that mesenchymal stem cells (MSCs) can enhance the regeneration of damaged tissue, modulate the inflammatory response, reduce the levels of fibrotic cytokines and reactive oxygen species, and inhibit epithelial-mesenchymal transformation. Interestingly, MSCs can also exert immunosuppressive effects, which highlights a new potential therapeutic activity of MSCs for managing RILI. Here, we reviewed the potential applications and therapeutic mechanisms of action of MSCs in RILI, which will represent a good compendium of information for researchers in this field.
ISSN:1757-6512
1757-6512
DOI:10.1186/s13287-021-02279-9