Fate decisions of breast cancer stem cells in cancer progression

Breast cancer has a marked recurrence and metastatic trait and is one of the most prevalent malignancies affecting women’s health worldwide. Tumor initiation and progression begin after the cell goes from a quiescent to an activated state and requires different mechanisms to act in concert to regula...

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Bibliographic Details
Published in:Frontiers in oncology 2022-08, Vol.12, p.968306-968306
Main Authors: Xu, Hui, Zhang, Fengxia, Gao, Xiaokang, Zhou, Qiwang, Zhu, Linhai
Format: Article
Language:English
Subjects:
breast cancer
breast cancer stem cells
heterogeneity
non-coding RNAs
Oncology
transcription factors
tumor microenvironment
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Summary:Breast cancer has a marked recurrence and metastatic trait and is one of the most prevalent malignancies affecting women’s health worldwide. Tumor initiation and progression begin after the cell goes from a quiescent to an activated state and requires different mechanisms to act in concert to regulate t a specific set of spectral genes for expression. Cancer stem cells (CSCs) have been proven to initiate and drive tumorigenesis due to their capability of self-renew and differentiate. In addition, CSCs are believed to be capable of causing resistance to anti-tumor drugs, recurrence and metastasis. Therefore, exploring the origin, regulatory mechanisms and ultimate fate decision of CSCs in breast cancer outcomes has far-reaching clinical implications for the development of breast cancer stem cell (BCSC)-targeted therapeutic strategies. In this review, we will highlight the contribution of BCSCs to breast cancer and explore the internal and external factors that regulate the fate of BCSCs.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2022.968306