Anticancer effects of exercise: Insights from single-cell analysis

•Physical exercise can exert antitumorigenic effects; however, the molecular mechanisms are still poorly understood.•Single-cell analysis may help to characterize the molecular mechanisms underlying the effects of exercise on anticancer immune function as well as on the complex tumor microenvironmen...

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Bibliographic Details
Published in:Journal of sport and health science 2024-09, Vol.13 (5), p.676-678
Main Authors: Plaza-Florido, Abel, Lucia, Alejandro, Radom-Aizik, Shlomit, Fiuza-Luces, Carmen
Format: Article
Language:English
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Summary:•Physical exercise can exert antitumorigenic effects; however, the molecular mechanisms are still poorly understood.•Single-cell analysis may help to characterize the molecular mechanisms underlying the effects of exercise on anticancer immune function as well as on the complex tumor microenvironment.•Recent research using single-cell analysis provides preliminary insights into the molecular mechanisms behind an improved antitumor immunity in response to exercise. Particularly, there is evidence for a “reprogramming” of several immune effectors towards a higher antitumoral toxicity.
ISSN:2095-2546
2213-2961
2213-2961
DOI:10.1016/j.jshs.2024.01.008