Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates

A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.

Saved in:
Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2019-10, Vol.24 (21), p.3846
Main Authors: Tomassetti, Mara, Lupidi, Gabriele, Piermattei, Pamela, Rossi, Federico V, Lillini, Samuele, Bianchini, Gianluca, Aramini, Andrea, Ciufolini, Marco A, Marcantoni, Enrico
Format: Article
Language:English
Subjects:
5-acylamino-1,3-thiazoles
Alzheimer's disease
Catalysis
Catalysts
Chemistry
Cyclization
hantzsch reaction
Molecular Structure
Pharmaceutical sciences
Thiazoles
Thiazoles - chemical synthesis
Thiazoles - chemistry
α-chloroglycinates
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules24213846