Acellular allogeneic nerve grafting combined with bone marrow mesenchymal stem cell transplantation for the repair of long-segment sciatic nerve defects：biomechanics and validation of mathematical models

We hypothesized that a chemically extracted acellular allogeneic nerve graft used in combination with bone marrow mesenchymal stem cell transplantation would be an effective treatment for long-segment sciatic nerve defects.To test this,we established rabbit models of 30 mm sciatic nerve defects,and...

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Published in:Neural regeneration research 2016-08, Vol.11 (8), p.1322-1326
Main Authors: Li, Ya-jun, Zhao, Bao-lin, Lv, Hao-ze, Qin, Zhi-gang, Luo, Min
Format: Article
Language:English
Subjects:
Analysis
Animals
Biomechanics
Bone marrow
Defects
Electrodes
Electromyography
Electrophysiology
Humidity
Mechanical properties
nerve regeneration
chemically extracted acellular allogeneic nerve graft
autograft
bone marrow mesenchymal stem cells
sciatic nerve defects
biomechanics
electrophysiology
morphology
neural regeneration
Ostomy
Penicillin
Physiology
Sciatic nerve
Stem cell transplantation
修复
干细胞移植
数学模型
生物力学
神经移植
神经缺损
验证
骨髓间充质干细胞
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cited_by cdi_FETCH-LOGICAL-c680a-9eeea85c43e02e760d229117e6949c72cbac6bc0a2bed8d0f0503976e263c403
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Luo, Min
description We hypothesized that a chemically extracted acellular allogeneic nerve graft used in combination with bone marrow mesenchymal stem cell transplantation would be an effective treatment for long-segment sciatic nerve defects.To test this,we established rabbit models of 30 mm sciatic nerve defects,and treated them using either an autograft or a chemically decellularized allogeneic nerve graft with or without simultaneous transplantation of bone marrow mesenchymal stem cells.We compared the tensile properties,electrophysiological function and morphology of the damaged nerve in each group.Sciatic nerves repaired by the allogeneic nerve graft combined with stem cell transplantation showed better recovery than those repaired by the acellular allogeneic nerve graft alone,and produced similar results to those observed with the autograft.These findings confirm that a chemically extracted acellular allogeneic nerve graft combined with transplantation of bone marrow mesenchymal stem cells is an effective method of repairing long-segment sciatic nerve defects.
doi_str_mv 10.4103/1673-5374.189198
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subjects Analysis
Animals
Biomechanics
Bone marrow
Defects
Electrodes
Electromyography
Electrophysiology
Humidity
Mechanical properties
nerve regeneration
chemically extracted acellular allogeneic nerve graft
autograft
bone marrow mesenchymal stem cells
sciatic nerve defects
biomechanics
electrophysiology
morphology
neural regeneration
Ostomy
Penicillin
Physiology
Sciatic nerve
Stem cell transplantation
修复
干细胞移植
数学模型
生物力学
神经移植
神经缺损
验证
骨髓间充质干细胞
title Acellular allogeneic nerve grafting combined with bone marrow mesenchymal stem cell transplantation for the repair of long-segment sciatic nerve defects：biomechanics and validation of mathematical models
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