Reproducibility of continuous glucose monitoring results under real-life conditions in an adult population: a functional data analysis

Continuous glucose monitoring systems (CGM) are a very useful tool to understand the behaviour of glucose in different situations and populations. Despite the widespread use of CGM systems in both clinical practice and research, our understanding of the reproducibility of CGM data remains limited. T...

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Bibliographic Details
Published in:Scientific reports 2023-08, Vol.13 (1), p.13987-13987, Article 13987
Main Authors: Matabuena, Marcos, Pazos-Couselo, Marcos, Alonso-Sampedro, Manuela, Fernández-Merino, Carmen, González-Quintela, Arturo, Gude, Francisco
Format: Article
Language:English
Subjects:
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Correlation coefficient
Data analysis
Diabetes
Diabetes mellitus
Glucose monitoring
Humanities and Social Sciences
multidisciplinary
Reproducibility
Science
Science (multidisciplinary)
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Summary:Continuous glucose monitoring systems (CGM) are a very useful tool to understand the behaviour of glucose in different situations and populations. Despite the widespread use of CGM systems in both clinical practice and research, our understanding of the reproducibility of CGM data remains limited. The present work examines the reproducibility of the results provided by a CGM system in a random sample of a free-living adult population, from a functional data analysis approach. Functional intraclass correlation coefficients (ICCs) and their 95% confidence intervals (CI) were calculated to assess the reproducibility of CGM results in 581 individuals. 62% were females 581 participants (62% women) mean age 48 years (range 18–87) were included, 12% had previously been diagnosed with diabetes. The inter-day reproducibility of the CGM results was greater for subjects with diabetes (ICC 0.46 [CI 0.39–0.55]) than for normoglycaemic subjects (ICC 0.30 [CI 0.27–0.33]); the value for prediabetic subjects was intermediate (ICC 0.37 [CI 0.31–0.42]). For normoglycaemic subjects, inter-day reproducibility was poorer among the younger (ICC 0.26 [CI 0.21–0.30]) than the older subjects (ICC 0.39 [CI 0.32–0.45]). Inter-day reproducibility was poorest among normoglycaemic subjects, especially younger normoglycaemic subjects, suggesting the need to monitor some patient groups more often than others.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-40949-1