Osteo-inductive effect of piezoelectric stimulation from the poly(l-lactic acid) scaffolds

Piezoelectric biomaterials can generate piezoelectrical charges in response to mechanical activation. These generated charges can directly stimulate bone regeneration by triggering signaling pathway that is important for regulating osteogenesis of cells seeded on the materials. On the other hand, me...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2024-02, Vol.19 (2), p.e0299579-e0299579
Main Authors: Das, Ritopa, Le, Duong, Kan, Ho-Man, Le, Thinh T, Park, Jinyoung, Nguyen, Thanh D, Lo, Kevin W-H
Format: Article
Language:English
Subjects:
Analysis
Biological products
Biology and Life Sciences
Bone regeneration
Cell differentiation
Ethylenediaminetetraacetic acid
Evaluation
Lactic acid
Medicine and Health Sciences
Methods
Properties
Research and Analysis Methods
Stem cells
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Piezoelectric biomaterials can generate piezoelectrical charges in response to mechanical activation. These generated charges can directly stimulate bone regeneration by triggering signaling pathway that is important for regulating osteogenesis of cells seeded on the materials. On the other hand, mechanical forces applied to the biomaterials play an important role in bone regeneration through the process called mechanotransduction. While mechanical force and electrical charges are both important contributing factors to bone tissue regeneration, they operate through different underlying mechanisms. The utilizations of piezoelectric biomaterials have been explored to serve as self-charged scaffolds which can promote stem cell differentiation and the formation of functional bone tissues. However, it is still not clear how mechanical activation and electrical charge act together on such a scaffold and which factors play more important role in the piezoelectric stimulation to induce osteogenesis. In our study, we found Poly(l-lactic acid) (PLLA)-based piezoelectric scaffolds with higher piezoelectric charges had a more pronounced osteoinductive effect than those with lower charges. This provided a new mechanistic insight that the observed osteoinductive effect of the piezoelectric PLLA scaffolds is likely due to the piezoelectric stimulation they provide, rather than mechanical stimulation alone. Our findings provide a crucial guide for the optimization of piezoelectric material design and usage.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0299579