Association of genetic variants of the vitamin D receptor gene with vitiligo in a tertiary care center in a Saudi population: a case-control study

Vitiligo is a common cutaneous disorder of the skin and hair caused by a systemic depigmentation disorder that affects 1% of the population or less due to its onset in early adulthood. Meta-analyses have documented a linkage between vitiligo and the vitamin D receptor ( ) gene. Investigate the relat...

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Bibliographic Details
Published in:Annals of Saudi medicine 2022-03, Vol.42 (2), p.96-106
Main Authors: Saif, Ghada Bin, Khan, Imran Ali
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Female
Genetic Predisposition to Disease
Humans
Male
Original
Polymorphism, Single Nucleotide
Receptors, Calcitriol - genetics
Saudi Arabia - epidemiology
Tertiary Care Centers
Vitiligo - epidemiology
Vitiligo - genetics
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Summary:Vitiligo is a common cutaneous disorder of the skin and hair caused by a systemic depigmentation disorder that affects 1% of the population or less due to its onset in early adulthood. Meta-analyses have documented a linkage between vitiligo and the vitamin D receptor ( ) gene. Investigate the relationship between the ApaI, BsmI, FokI and TaqI genetic variants in the gene with vitiligo in a Saudi population. Case-control. Single tertiary care center. The case-control study was carried out between January 2015-December 2015 in Saudi vitiligo patients and healthy controls. genetic variants or polymorphisms (ApaI, BsmI, FokI and TaqI) were genotyped by polymerase chain reaction-restriction fragment length analysis followed by 3% agarose gel electrophoresis. Applicable statistical methods were used to assess relationships between vitiligo cases and controls. Effect of genotype distribution among four single nucleotide polymorphisms. 152 vitiligo (median [IQR] 23 [19] years) patients and 159 healthy controls (45 [28.5] years). We found an association of vitiligo with ApaI and BsmI polymorphisms (
ISSN:0256-4947
0975-4466
DOI:10.5144/0256-4947.2022.96