Effective Synthesis of Deuterated n-Octylamine and Its Analogues

In neutron scattering studies, deuterium-labelled compounds play a key role in controlling the contrast of organic samples and reducing the incoherent scattering background from the samples. As amine compounds play a vital role as functional molecules, we have developed a new synthesis method using...

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Bibliographic Details
Published in:EPJ Web of conferences 2023, Vol.286, p.1004
Main Authors: Akutsu-Suyama, Kazuhiro, Ueda, Misaki, Shibayama, Mitsuhiro, Ishii, Kosuke, Nishi, Naoya
Format: Article
Language:English
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Summary:In neutron scattering studies, deuterium-labelled compounds play a key role in controlling the contrast of organic samples and reducing the incoherent scattering background from the samples. As amine compounds play a vital role as functional molecules, we have developed a new synthesis method using an amide compound as a starting material to synthesize deuterated amines and their analogues. We determined the deuteration ratio of the obtained deuterated 1-octylamine by mass spectrometry, nuclear magnetic resonance (NMR), and neutron reflectometry techniques. As a result, the deuteration ratio was estimated to be ~60 %. The deuteration ratio of the synthesized 1-octylamine was not high because the method used did not deuterate its α -protons and NH 2 group. However, this synthesis method is suitable for the large-scale synthesis of deuterated amine compounds for neutron research because it is easy to increase the synthetic scale.
ISSN:2100-014X
2100-014X
DOI:10.1051/epjconf/202328601004