The use of integrin binding domain loaded hydrogel (RGD) with minimally invasive surgical technique in treatment of periodontal intrabony defect: a randomized clinical and biochemical study

Periodontal regeneration faces multiple challenges, the most important being cellular insufficiency. In an attempt to improve defect cellularity, we aimed to demonstrate enhancing cellular attraction using arginine-glycine-aspartic acid (RGD) adhesion molecule legend blended hydrogel within the intr...

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Bibliographic Details
Published in:Journal of applied oral science 2023-01, Vol.31, p.e20230263-e20230263
Main Authors: Abd El-Azeem, Shaimaa Hamdy, Khalil, Ahmed Abdallah, Ibrahim, Mohammed Abdel-Moniem, Gamal, Ahmed Y
Format: Article
Language:English
Subjects:
Alveolar Bone Loss - drug therapy
Alveolar Bone Loss - surgery
DENTISTRY, ORAL SURGERY & MEDICINE
Follow-Up Studies
Guided Tissue Regeneration, Periodontal - methods
Humans
Hydrogel
Hydrogels
Integrin
Integrins
Minimally Invasive Surgical Procedures
Minimally invasive surgical technique
Oligopeptides
Periodontal Attachment Loss
Periodontal Pocket
Periodontal regeneration
RGD peptide
Treatment Outcome
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Summary:Periodontal regeneration faces multiple challenges, the most important being cellular insufficiency. In an attempt to improve defect cellularity, we aimed to demonstrate enhancing cellular attraction using arginine-glycine-aspartic acid (RGD) adhesion molecule legend blended hydrogel within the intrabony defects. Forty-five intrabony defects were selected from patients with stage III or IV - grade A or B periodontitis and divided randomly into three equal groups of 15 each: group1 (G1): received minimally invasive surgical technique (MIST) alone, group2 (G2): received MIST and placebo hydrogel injection, and group3 (G3): were treated with MIST and RGD hydrogel injection. Primary outcomes 6 months following therapy were; defect base fill (DBF) and defect width measurement (DW); secondary outcomes were clinical attachment level (CAL), pocket depth (PD), plaque index (PI), gingival index (GI), and biochemical analysis of bone morphogenetic protein (BMP-2) evaluated at 1,7,14 and 21 days following therapy. Significant improvements in DBF, CAL, and PD were observed in the three studied groups 6 months following therapy compared to baseline (p
ISSN:1678-7757
1678-7765
1678-7765
DOI:10.1590/1678-7757-2023-0263