Long-term measles antibody profiles following different vaccine schedules in China, a longitudinal study

Characterizing the long-term kinetics of maternally derived and vaccine-induced measles immunity is critical for informing measles immunization strategies moving forward. Based on two prospective cohorts of children in China, we estimate that maternally derived immunity against measles persists for...

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Published in:Nature communications 2023-03, Vol.14 (1), p.1746-1746, Article 1746
Main Authors: Wang, Qianli, Wang, Wei, Winter, Amy K., Zhan, Zhifei, Ajelli, Marco, Trentini, Filippo, Wang, Lili, Li, Fangcai, Yang, Juan, Xiang, Xingyu, Liao, Qiaohong, Zhou, Jiaxin, Guo, Jinxin, Yan, Xuemei, Liu, Nuolan, Metcalf, C. Jessica E., Grenfell, Bryan T., Yu, Hongjie
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Language:English
Subjects:
101/1
631/326/590
631/326/596/1631
692/699/255/2514
692/700/478/174
Adolescent
Antibodies
Antibodies, Viral
Child
Children
China - epidemiology
Health risks
Humanities and Social Sciences
Humans
Immune response
Immune system
Immunity
Immunization
Infant
Kinetics
Longitudinal Studies
Measles
Measles - epidemiology
Measles - prevention & control
Measles Vaccine
multidisciplinary
Prospective Studies
Schedules
Science
Science (multidisciplinary)
Vaccination
Vaccines
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cited_by cdi_FETCH-LOGICAL-c541t-7b76f13568a7dc1c9946830b263f50c6465a3f7cd72203df44b50ac86550d9df3
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container_end_page 1746
container_issue 1
container_start_page 1746
container_title Nature communications
container_volume 14
creator Wang, Qianli
Wang, Wei
Winter, Amy K.
Zhan, Zhifei
Ajelli, Marco
Trentini, Filippo
Wang, Lili
Li, Fangcai
Yang, Juan
Xiang, Xingyu
Liao, Qiaohong
Zhou, Jiaxin
Guo, Jinxin
Yan, Xuemei
Liu, Nuolan
Metcalf, C. Jessica E.
Grenfell, Bryan T.
Yu, Hongjie
description Characterizing the long-term kinetics of maternally derived and vaccine-induced measles immunity is critical for informing measles immunization strategies moving forward. Based on two prospective cohorts of children in China, we estimate that maternally derived immunity against measles persists for 2.4 months. Following two-dose series of measles-containing vaccine (MCV) at 8 and 18 months of age, the immune protection against measles is not lifelong, and antibody concentrations are extrapolated to fall below the protective threshold of 200 mIU/ml at 14.3 years. A catch-up MCV dose in addition to the routine doses between 8 months and 5 years reduce the cumulative incidence of seroreversion by 79.3–88.7% by the age of 6 years. Our findings also support a good immune response after the first MCV vaccination at 8 months. These findings, coupled with the effectiveness of a catch-up dose in addition to the routine doses, could be instrumental to relevant stakeholders when planning routine immunization schedules and supplemental immunization activities. The timing of measles vaccination in infants affects the risk of infection in young children and the duration of protection provided. Here, the authors investigate optimal vaccination timing by characterising antibody kinetics following different vaccine schedules in two cohorts of children in southern China.
doi_str_mv 10.1038/s41467-023-37407-x
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subjects 101/1
631/326/590
631/326/596/1631
692/699/255/2514
692/700/478/174
Adolescent
Antibodies
Antibodies, Viral
Child
Children
China - epidemiology
Health risks
Humanities and Social Sciences
Humans
Immune response
Immune system
Immunity
Immunization
Infant
Kinetics
Longitudinal Studies
Measles
Measles - epidemiology
Measles - prevention & control
Measles Vaccine
multidisciplinary
Prospective Studies
Schedules
Science
Science (multidisciplinary)
Vaccination
Vaccines
title Long-term measles antibody profiles following different vaccine schedules in China, a longitudinal study
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