Interleukins: Pathogenesis in Non-Alcoholic Fatty Liver Disease

Inflammatory cytokines have been implicated as crucial contributors to the onset and progression of non-alcoholic fatty liver disease (NAFLD). The exact mechanisms by which interleukins (ILs) contribute to NAFLD may vary, and ongoing research is aimed at understanding the specific roles of different...

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Bibliographic Details
Published in:Metabolites 2024-03, Vol.14 (3), p.153
Main Authors: Rafaqat, Saira, Gluscevic, Sanja, Mercantepe, Filiz, Rafaqat, Sana, Klisic, Aleksandra
Format: Article
Language:English
Subjects:
Body fat
Cytokines
Development and progression
Drug therapy
Environmental factors
Fatty acids
Fatty liver
Health aspects
Immunosuppressive agents
Inflammation
Insulin resistance
Interleukins
Kinases
Liver diseases
Metabolic syndrome
MicroRNAs
non-alcoholic fatty liver disease
Obesity
Oxidative stress
Pathogenesis
Physiological aspects
Proteins
Review
Tumor necrosis factor-TNF
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Summary:Inflammatory cytokines have been implicated as crucial contributors to the onset and progression of non-alcoholic fatty liver disease (NAFLD). The exact mechanisms by which interleukins (ILs) contribute to NAFLD may vary, and ongoing research is aimed at understanding the specific roles of different ILs in the pathogenesis of this condition. In addition, variations in environmental factors and genetics in each individual can influence the onset and/or progression of NAFLD. The lack of clinical studies related to the potential therapeutic properties of IL-1 inhibitors currently does not allow us to conclude their validity as a therapeutic option, although preclinical studies show promising results. Further studies are needed to elucidate their beneficial properties in NAFLD treatment.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo14030153