Potential Misdiagnosis between COVID-19 and Dengue Infection Using Rapid Serological Test

The coronavirus disease 2019 (COVID-19) pandemic that has a significant rapid transmission is an international public health concern. Several dengue-endemic countries reported similar clinical and laboratory features between COVID-19 and dengue in the early incubation period, and thus discerning the...

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Bibliographic Details
Published in:Infectious disease reports 2021-06, Vol.13 (2), p.540-551
Main Authors: Khairunisa, Siti Qamariyah, Amarullah, Ilham Harlan, Churrotin, Siti, Fitria, Anisa Lailatul, Amin, Mochammad, Lusida, Maria Inge, Soegijanto, Soegeng
Format: Article
Language:English
Subjects:
Antibodies
Biosensors
Coronaviruses
COVID-19
COVID-19 diagnostic tests
Cross-reactivity
dengue
Dengue fever
Health care
Immunoglobulin G
Immunoglobulin M
Infections
Laboratories
Pandemics
Patients
Plasma
Polymerase chain reaction
Public health
rapid serological test
Respiratory diseases
Sars-Cov 2
Serology
Severe acute respiratory syndrome coronavirus 2
Vector-borne diseases
Viral diseases
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Summary:The coronavirus disease 2019 (COVID-19) pandemic that has a significant rapid transmission is an international public health concern. Several dengue-endemic countries reported similar clinical and laboratory features between COVID-19 and dengue in the early incubation period, and thus discerning the infection is difficult. As a dengue-endemic country, Indonesia also poses the same challenge during the COVID-19 outbreak. This current study analyzed the IgG and IgM profiles from COVID-19 patients by using a serological SARS-CoV-2 and dengue rapid test. In addition, 38 sera from healthy individuals (pre-COVID-19 date) were analyzed using a dengue rapid test. Among 120 samples, 4 samples indicated dengue IgG positive. However, IgM, NS1, and RT-PCR analyses showed negative results. Interestingly, regarding seropositivity of NS1 and DENV IgG from healthy individuals (pre COVID-19 infection), two samples were positive DENV IgG, while one of them was positive NS1. This suggested that in the dengue-endemic area, many people have already experienced dengue and have immunity against dengue virus. There is also the possibility of antibody cross-reactivity between COVID-19 and dengue infection. This also emphasizes the high demand for a rapid method with high sensitivity and specificity that can distinguish between SARS-CoV-2 and dengue.
ISSN:2036-7449
2036-7430
2036-7449
DOI:10.3390/idr13020050