Polymeric Nanoparticles for Mitochondria Targeting Mediated Robust Cancer Therapy

Despite all sorts of innovations in medical researches over the past decades, cancer remains a major threat to human health. Mitochondria are essential organelles in eukaryotic cells, and their dysfunctions contribute to numerous diseases including cancers. Mitochondria-targeted cancer therapy, whic...

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Bibliographic Details
Published in:Frontiers in bioengineering and biotechnology 2021-10, Vol.9, p.755727-755727
Main Authors: Sun, Yajing, Yang, Qingshan, Xia, Xue, Li, Xiaozhe, Ruan, Weimin, Zheng, Meng, Zou, Yan, Shi, Bingyang
Format: Article
Language:English
Subjects:
Bioengineering and Biotechnology
cancer therapy
drug delivery
mitochondria
nanoparticles
polymers
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Summary:Despite all sorts of innovations in medical researches over the past decades, cancer remains a major threat to human health. Mitochondria are essential organelles in eukaryotic cells, and their dysfunctions contribute to numerous diseases including cancers. Mitochondria-targeted cancer therapy, which specifically delivers drugs into the mitochondria, is a promising strategy for enhancing anticancer treatment efficiency. However, owing to their special double-layered membrane system and highly negative potentials, mitochondria remain a challenging target for therapeutic agents to reach and access. Polymeric nanoparticles exceed in cancer therapy ascribed to their unique features including ideal biocompatibility, readily design and synthesis, as well as flexible ligand decoration. Significant efforts have been put forward to develop mitochondria-targeted polymeric nanoparticles. In this review, we focused on the smart design of polymeric nanosystems for mitochondria targeting and summarized the current applications in improving cancer therapy.
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2021.755727