Serum Human Epididymis Protein 4 as a Prognostic Marker in Cervical Cancer

Objectives The objective is to evaluate the prognostic value of serum human epididymis protein 4 (HE4) as a tumor marker in patients with cervical cancer. Methods Sixty-seven patients with cervical cancer treated at Seoul National University Bundang Hospital from September 2014 to May 2018 were retr...

Full description

Saved in:
Bibliographic Details
Published in:Cancer control 2022-04, Vol.29, p.10732748221097778-10732748221097778
Main Authors: Hwang, Woo Yeon, Suh, Dong Hoon, Kim, Kidong, Kim, Yong Beom, No, Jae Hong
Format: Article
Language:English
Subjects:
Biomarkers, Tumor
Cervical cancer
Diagnosis
Epididymis
Female
Humans
Lymph nodes
Medical prognosis
Menopause
Metastases
Neoplasm Staging
Original
Patients
Post-menopause
Premenopause
Prognosis
Proteins - analysis
Proteins - metabolism
Retrospective Studies
Squamous cell carcinoma
Tumor markers
Tumors
Uterine Cervical Neoplasms
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives The objective is to evaluate the prognostic value of serum human epididymis protein 4 (HE4) as a tumor marker in patients with cervical cancer. Methods Sixty-seven patients with cervical cancer treated at Seoul National University Bundang Hospital from September 2014 to May 2018 were retrospectively reviewed. Serum HE4 levels were measured by immunoassay before starting primary treatment. A mean serum HE4 level of 72.6 pmol/L was used to divide the patients into low and high HE4 groups. Patient characteristics, clinicopathological variables, and survival outcomes were compared between the two groups. Results The low and high HE4 groups included 55 (82.1%) and 12 (17.9%) patients at diagnosis, respectively. Higher HE4 levels were significantly associated with older age at diagnosis (age
ISSN:1073-2748
1526-2359
1073-2748
DOI:10.1177/10732748221097778