Mesenchymal Stem Cells and Tissue Bioengineering Applications in Sheep as Ideal Model

The most common technologies in tissue engineering include growth factor therapies; metal implants, such as titanium; 3D bioprinting; nanoimprinting for ceramic/polymer scaffolds; and cell therapies, such as mesenchymal stem cells (MSCs). Cell therapy is a promising alternative to organ grafts and t...

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Bibliographic Details
Published in:Stem cells international 2024, Vol.2024 (1), p.5176251
Main Authors: Muniz, Talita D'Paula Tavares Pereira, Rossi, Mariana Correa, de Vasconcelos Machado, Vânia Maria, Alves, Ana Liz Garcia
Format: Article
Language:English
Subjects:
Animal genetic engineering
Animal models
Autoimmune diseases
B cells
Bioengineering
Biological products
Biomaterials
Biomedical materials
Body fat
Bone marrow
Cell differentiation
Cell self-renewal
Cell therapy
Clinical trials
Differentiation
Ethics
Growth factors
Immunomodulation
Mechanical properties
Mesenchymal stem cells
MicroRNAs
Musculoskeletal diseases
Polymers
Porosity
Regenerative medicine
Sheep
Skin & tissue grafts
Stem cell transplantation
Stem cells
Surgical implants
Tissue engineering
Titanium
Titanium alloys
Transplantation
Transplants
Umbilical cord
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Summary:The most common technologies in tissue engineering include growth factor therapies; metal implants, such as titanium; 3D bioprinting; nanoimprinting for ceramic/polymer scaffolds; and cell therapies, such as mesenchymal stem cells (MSCs). Cell therapy is a promising alternative to organ grafts and transplants in the treatment of numerous musculoskeletal diseases. MSCs have increasingly been used in generative medicine due to their specialized self-renewal, immunomodulation, multiplication, and differentiation properties. To further expand the potential of these cells in tissue repair, significant efforts are currently dedicated to the production of biomaterials with desirable short- and long-term biophysical properties that can aid the differentiation and expansion of MSCs. Biomaterials support MSC differentiation by modulating their characteristics, such as composition, mechanical properties, porosity, and topography. This review aimed to describe recent MSC approaches, including those associated with biomaterials, from experimental, clinical, and preclinical studies with sheep models.
ISSN:1687-966X
1687-9678
1687-9678
DOI:10.1155/2024/5176251