A Hippocampal Model for Behavioral Time Acquisition and Fast Bidirectional Replay of Spatio-Temporal Memory Sequences

The hippocampus is known to play a crucial role in the formation of long-term memory. For this, fast replays of previously experienced activities during sleep or after reward experiences are believed to be crucial. But how such replays are generated is still completely unclear. In this paper we prop...

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Bibliographic Details
Published in:Frontiers in neuroscience 2018-12, Vol.12, p.961-961
Main Authors: Matheus Gauy, Marcelo, Lengler, Johannes, Einarsson, Hafsteinn, Meier, Florian, Weissenberger, Felix, Yanik, Mehmet Fatih, Steger, Angelika
Format: Article
Language:English
Subjects:
Behavior
cholinergic modulation
Computer science
Decision making
Dopamine
hippocampal replays
Hippocampus
Long term memory
Memory
Neurons
Neuroscience
Neurosciences
one-shot learning
place cells
Reinforcement
reverse replays
Sleep
synfire chains
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Summary:The hippocampus is known to play a crucial role in the formation of long-term memory. For this, fast replays of previously experienced activities during sleep or after reward experiences are believed to be crucial. But how such replays are generated is still completely unclear. In this paper we propose a possible mechanism for this: we present a model that can store experienced trajectories on a behavioral timescale after a single run, and can subsequently bidirectionally replay such trajectories, thereby omitting any specifics of the previous behavior like speed, etc, but allowing repetitions of events, even with different subsequent events. Our solution builds on well-known concepts, one-shot learning and synfire chains, enhancing them by additional mechanisms using global inhibition and disinhibition. For replays our approach relies on dendritic spikes and cholinergic modulation, as supported by experimental data. We also hypothesize a functional role of disinhibition as a pacemaker during behavioral time.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2018.00961