HIV-1 Subtype distribution in morocco based on national sentinel surveillance data 2004-2005

Little is known about HIV-1 subtype distribution in Morocco. Some data suggest an emergence of new HIV subtypes. We conducted phylogenetic analysis on a nationally representative sample of 60 HIV-1 viral specimens collected during 2004-2005 through the Morocco national HIV sentinel surveillance surv...

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Bibliographic Details
Published in:AIDS research and therapy 2012-02, Vol.9 (1), p.5-5, Article 5
Main Authors: Akrim, Mohammed, Lemrabet, Sanae, Elharti, Elmir, Gray, Rebecca R, Tardy, Jean Claude, Cook, Robert L, Salemi, Marco, Andre, Patrice, Azarian, Taj, Aouad, Rajae El
Format: Article
Language:English
Subjects:
Care and treatment
Demographic aspects
Diagnosis
DNA sequencing
Epidemics
HIV infection
HIV-1
Medical geography
Methods
Morocco
Nucleotide sequencing
phylogeny
subtypes
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Summary:Little is known about HIV-1 subtype distribution in Morocco. Some data suggest an emergence of new HIV subtypes. We conducted phylogenetic analysis on a nationally representative sample of 60 HIV-1 viral specimens collected during 2004-2005 through the Morocco national HIV sentinel surveillance survey. While subtype B is still the most prevalent, 23.3% of samples represented non-B subtypes, the majority of which were classified as CRF02_AG (15%). Molecular clock analysis confirmed that the initial introduction of HIV-1B in Morocco probably came from Europe in the early 1980s. In contrast, the CRF02_AG strain appeared to be introduced from sub-Saharan Africa in two separate events in the 1990s. Subtype CRF02_AG has been emerging in Morocco since the 1990s. More information about the factors introducing HIV subtype-specific transmission will inform the prevention strategy in the region.
ISSN:1742-6405
1742-6405
DOI:10.1186/1742-6405-9-5