Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition

Abstract Exercise is a treatment paradigm that can ameliorate cognitive dysfunction in Alzheimer disease (AD) and AD mouse models. Since exercise is also known to alter the peripheral immune response, one potential mechanism for the cognitive improvement following exercise may be by modulating the i...

Full description

Saved in:
Bibliographic Details
Published in:Neurobiology of disease 2008-04, Vol.30 (1), p.121-129
Main Authors: Parachikova, A, Nichol, K.E, Cotman, C.W
Format: Article
Language:English
Subjects:
AD model
Aging
Alzheimer disease
Alzheimer Disease - complications
Alzheimer Disease - genetics
Alzheimer Disease - rehabilitation
Amyloid beta-Peptides - metabolism
Amyloid beta-Protein Precursor - genetics
Animals
Behavior, Animal
Chemokine CXCL1 - genetics
Chemokine CXCL1 - metabolism
Chemokine CXCL2 - genetics
Chemokine CXCL2 - metabolism
Cognition
Cognition - physiology
CXCL1
CXCL12
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay - methods
Exercise
Gene Expression Regulation - physiology
Inflammation
Inflammation - etiology
Inflammation - rehabilitation
Maze Learning - physiology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Microarray Analysis
Neuroinflammation
Neurology
RNA, Messenger - metabolism
Running
Tg2576
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Exercise is a treatment paradigm that can ameliorate cognitive dysfunction in Alzheimer disease (AD) and AD mouse models. Since exercise is also known to alter the peripheral immune response, one potential mechanism for the cognitive improvement following exercise may be by modulating the inflammatory repertoire in the central nervous system. We investigated the effects of voluntary exercise in the Tg2576 mouse model of AD at a time-point at which pathology has already developed. Inflammatory mRNA markers are increased in sedentary Tg2576 mice versus non-transgenic controls. We demonstrate that short-term voluntary wheel running improved spatial learning in aged transgenic mice as compared to sedentary Tg2576 controls. Inflammatory profiles of the Tg2576 and non-transgenic mice were different following exercise with the non-transgenic mice showing a broader response as compared to the Tg2576. Notably, exercising Tg2576 exhibited increases in a few markers including CXCL1 and CXCL12, two chemokines that may affect cognition.
ISSN:0969-9961
1095-953X
DOI:10.1016/j.nbd.2007.12.008