Preceding exercise and postprandial hypertriglyceridemia: effects on lymphocyte cell DNA damage and vascular inflammation

Exercise has proved effective in attenuating the unfavourable response normally associated with postprandial hypertriglyceridemia (PHTG) and accompanying oxidative stress. Yet, the acute effects of prior exercise and PHTG on DNA damage remains unknown. The purpose of this study was to examine if wal...

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Bibliographic Details
Published in:Lipids in health and disease 2019-05, Vol.18 (1), p.125-125, Article 125
Main Authors: Brown, Malcolm, McClean, Conor M, Davison, Gareth W, Brown, John C W, Murphy, Marie H
Format: Article
Language:English
Subjects:
Acute effects
Aerobics
Antioxidants
Care and treatment
Cytokines
Deoxyribonucleic acid
DNA
DNA damage
Exercise
Exercise intensity
Health aspects
Heart rate
Hyperlipidemia
Hypertriglyceridemia
Inflammation
Lipid metabolism
Lipid peroxidation
Lipids
Lipoproteins
Lymphocytes
Metabolism
Oxidation
Oxidative stress
Physical fitness
Physical training
Postprandial hypertriglyceridemia
Proteins
Respiration
Retinol-binding protein
Studies
Triglycerides
Tumor necrosis factor-TNF
Vitamin A
Walking
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Summary:Exercise has proved effective in attenuating the unfavourable response normally associated with postprandial hypertriglyceridemia (PHTG) and accompanying oxidative stress. Yet, the acute effects of prior exercise and PHTG on DNA damage remains unknown. The purpose of this study was to examine if walking alters PHTG-induced oxidative damage and the interrelated inflammatory mechanisms. Twelve apparently healthy, recreationally active, male participants (22.4 ± 4.1 years; 179.2 ± 6 cm; 84.2 ± 14.7 kg; 51.3 ± 8.6 ml·kg ·min ) completed a randomised, crossover study consisting of two trials: (1) a high-fat meal alone (resting control) or (2) a high-fat meal immediately following 1 h of moderate exercise (65% maximal heart rate). Venous blood samples were collected at baseline, immediately post-exercise or rest, as well as at 2, 4 and 6 h post-meal. Biomarkers of oxidative damage (DNA single-strand breaks, lipid peroxidation and free radical metabolism) and inflammation were determined using conventional biochemistry techniques. DNA damage, lipid peroxidation, free radical metabolism and triglycerides increased postprandially (main effect for time, p 
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-019-1071-y