Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age—A Retrospective Study

We aimed to investigate the significance of optical coherence tomography (SD-OCT) in managing pediatric optic pathway gliomas (OPGs) in children younger than 5 years of age. A retrospective monocentric study was conducted. SD-OCT scans were obtained using the handheld iVue system to assess peripapil...

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Bibliographic Details
Published in:Children (Basel) 2022-08, Vol.9 (9), p.1307
Main Authors: Pavone, Rossana, Fonte, Carla, Sardi, Iacopo, Caputo, Roberto, Marziali, Elisa, Mazzeo, Fabio, Secci, Jacopo, Bergamini, Alessia, De Masi, Salvatore, Leo, Maria Carmela, Censullo, Maria Luigia, Bacci, Giacomo Maria
Format: Article
Language:English
Subjects:
Chemotherapy
Childrens health
Classification
Comparative analysis
CT imaging
Development and progression
Genetic disorders
Glioma
Gliomas
Magnetic resonance imaging
Medical prognosis
Methods
neurofibromatosis
Neurological disorders
OPG
Optic nerve
optic pathway glioma
optical coherence tomography
Optics
Patients
Pediatrics
pRNFL
Radiation therapy
SD-OCT
Software
Tomography
Tumors
Values
Citations: Items that this one cites
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Summary:We aimed to investigate the significance of optical coherence tomography (SD-OCT) in managing pediatric optic pathway gliomas (OPGs) in children younger than 5 years of age. A retrospective monocentric study was conducted. SD-OCT scans were obtained using the handheld iVue system to assess peripapillary retinal nerve fibre layer (pRNFL) thickness at three time points: baseline (OCT1), end of treatment (OCT2), and at last follow-up (OCT3). We compared the median value of pRNFL (and interquartile range—IQR) at different follow-up times and in different sub-groups (stable disease—SD, partial response—PR, and progression disease—PD). Thirteen children younger than 5 years of age were included. The Median follow-up time was 3.9 years (IQR 1.2). Six patients showed a pRNFL change of more than 10% during follow-up. Seven patients showed PD during follow-up. Median pRNFL at baseline was 81.5 µm (IQR 31.5); median pRNFL at the end of treatment was 73 µm (IQR 33); median pRNFL at last follow-up was 72 µm (IQR 38.5). The mean pRNFL at baseline was significantly lower than the mean normative values. Only subjects with PD showed pRNFL change close to statistical significance. This study confirms the role of SD-OCT in managing OPGs for therapeutic decisions and strategy planning of visual rehabilitation.
ISSN:2227-9067
2227-9067
DOI:10.3390/children9091307