The Role of Radiation Therapy in the Management of Prostate Cancer and Posttreatment Imaging Appearances

• Published in: Journal of Gastrointestinal and Abdominal Radiology 2024-09, Vol.7 (3), p.203-214
• Main Authors: Ghosh, Soumyadeep, Rosen, Daniel B., Pandey, Ankur, Nakrour, Nabih, Prajapati, Priyanka, Harisinghani, Mukesh, Kamran, Sophia C.
• Format: Article
• Language: English
• Subjects: brachytherapy; external beam radiation therapy; post radiation complications; posttreatment imaging appearances; prostate cancer; proton beam therapy
• ISSN: 2581-9178; 2581-9178
• DOI: 10.1055/s-0044-1782203

Prostate cancer remains a significant global health concern, necessitating continuous research and innovation in treatment modalities. This review explores the currently employed techniques in radiation dose planning and tumor irradiation in the context of prostate cancer management. In addition, we delve into the nuances of expected posttreatment magnetic resonance imaging (MRI) appearances within the gland or in the prostate bed, postradiation tumor recurrence, and its mimics. Radiation therapy (RT) has evolved as a cornerstone in prostate cancer treatment, offering both curative and palliative solutions. Recent developments have seen the emergence of advanced techniques such as intensity-modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT), allowing for precise targeting of cancer cells while minimizing damage to surrounding healthy tissue. The avoidance of normal tissue dose through more conformal dose distribution as in IMRT or proton therapy, improved imaging modalities as in multiparametric magnetic resonance imaging (mpMRI) and prostate positron emission tomography (PET), interventional separation of critical structures from the prostate target, and many other techniques can greatly reduce the side effects of RT. These advancements enhance treatment efficacy and reduce the risk of side effects, promoting improved patient outcomes.