Hepatitis E virus serum antibodies and RNA prevalence in patients evaluated for heart and kidney transplantation

AbstractBackground. Acute hepatitis E virus (HEV) infection in solid organ transplant recipients is rare, but can cause severe hepatic and extrahepatic complications. We sought to identify the pretransplant prevalence of HEV infection in heart and kidney candidates and any associated risk factors fo...

Full description

Saved in:
Bibliographic Details
Published in:Annals of hepatology 2016, Vol.15 (1), p.33-40
Main Authors: Unzueta, Alberto, M.D, Valdez, Riccardo, Chang, Yu-Hui H, Desmarteau, Yvonne M, Heilman, Raymond L, Scott, Robert L, Douglas, David D, Rakela, Jorge
Format: Article
Language:English
Subjects:
Adult
Age Factors
Biomarkers - blood
Diagnosis
Enzyme-Linked Immunosorbent Assay
Epidemiology
Female
Gastroenterology and Hepatology
Heart Transplantation
Hepatitis Antibodies - blood
Hepatitis E - blood
Hepatitis E - diagnosis
Hepatitis E - epidemiology
Hepatitis E - virology
Hepatitis E virus - genetics
Hepatitis E virus - immunology
Humans
Kidney Transplantation
Male
Middle Aged
Molecular Epidemiology
Multivariate Analysis
Nucleic Acid Amplification Techniques
Odds Ratio
Predictive Value of Tests
Prevalence
Risk Factors
RNA, Viral - blood
Seroepidemiologic Studies
Southwestern United States - epidemiology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:AbstractBackground. Acute hepatitis E virus (HEV) infection in solid organ transplant recipients is rare, but can cause severe hepatic and extrahepatic complications. We sought to identify the pretransplant prevalence of HEV infection in heart and kidney candidates and any associated risk factors for infection. Material and methods. Stored frozen serum from patients undergoing evaluation for transplant was tested for HEV immunoglobulin G (IgG) antibodies and HEV RNA. All patients were seen at Mayo Clinic Hospital, Phoenix, Arizona, with 333 patients evaluated for heart (n = 132) or kidney (n = 201) transplant. HEV IgG antibodies (anti-HEV IgG) were measured by enzyme-linked immunosorbent assay, and HEV RNA by a noncommercial nucleic acid amplification assay. Results. The prevalence of anti-HEV IgG was 11.4% (15/132) for heart transplant candidates and 8.5% (17/201) for kidney transplant candidates, with an overall seroprevalence of 9.6% (32/333). None of the patients tested positive for HEV RNA in the serum. On multivariable analysis, age older than 60 years was associated with HEV infection (adjusted odds ratio, 3.34; 95% CI, 1.54-7.24; P = 0.002). Conclusions. We conclude that there was no evidence of acute HEV infection in this pretransplant population and that older age seems to be associated with positive anti-HEV IgG.
ISSN:1665-2681
DOI:10.5604/16652681.1184202