Cortical auditory evoked potential in assessment of neonates: a study about minimum level of responses in term and preterm newborns

• Published in: Brazilian journal of otorhinolaryngology 2020-11, Vol.86 (6), p.687-695
• Main Authors: Didoné, Dayane Domeneghini, Oliveira, Lilian Sanches, Durante, Alessandra Spada, Almeida, Kátia de, Garcia, Michele Vargas, Riesgo, Rudimar dos Santos, Sleifer, Pricila
• Format: Article
• Language: English
• Subjects: Auditory threshold; Electrophysiology; Eletrofisiologia; Evoked potentials, auditory; Infant, newborn; Limiar auditivo; Original; OTORHINOLARYNGOLOGY; Potenciais evocados auditivos; Recém-nascido
• ISSN: 1808-8694; 1808-8686; 1808-8686
• DOI: 10.1016/j.bjorl.2019.04.009

The study of the threshold level of cortical auditory response in adults has been investigated in previous studies. Due to maturational issues, little is known about these responses in neonates. Technological advances with automatic analysis devices now allow investigation in specific populations. Thus, new studies are needed to establish the feasibility of using this auditory potential to identify the lowest levels of responses in children. Verify and compare latency and amplitude in 80dBnNA and the minimum level of cortical auditory response in term and preterm neonates. A cross-sectional, comparative study involving 59 neonates, 35 full-term births and 24 preterm births, with positive results in the Neonatal Hearing Screening. The Hearlab system was used to investigate the P1i auditory potential with tone burst stimulus at frequencies of 500, 1000, 2000 and 4000Hz. The minimum response level search ranged from 80 to 0dBNA and was detected automatically. The results were compared between groups, evaluating the latency and amplitude in 80dBNA and the minimum level of cortical auditory response. The mean values obtained for the minimum level of cortical auditory response in term group were 26±8.81; 26.14±6.97; 29±7.65 and 29.43±7.04dBNA and for preterm neonates of 31.96±10.41; 34.13±11.34; 33.64±11.03 and 37.73±11.92dBNA, for the frequencies of 500, 1000, 2000 and 4000Hz, respectively. There was a difference between groups for the latency of P1i at 4000Hz and the minimum response levels at 500, 1000 and 4000Hz, with higher values for preterm infants. It was possible to obtain latency and amplitude values at 80dBnNA and the minimum level of cortical response in term and preterm newborns, with different results between groups, with higher values in those born preterm. A investigação do nível mínimo de resposta auditiva cortical tem sido alvo de diferentes estudos em adultos. Devido a questões de maturação, pouco se sabe sobre essas respostas em recém-nascidos. Com o avanço tecnológico, dispositivos de análise automática surgiram com o objetivo de retomar essa avaliação em populações específicas. Assim, novos estudos são necessários para verificar a viabilidade do uso desse potencial auditivo na obtenção de níveis mínimos de respostas na criança. Verificar e comparar latência e amplitude em 80dBnNA e o nível mínimo de resposta auditiva cortical em recém-nascidos a termo e pré-termo. Estudo transversal, comparativo, envolvendo 59 neonatos, 35 nascidos a termo