A comparative evaluation of the efficacy of probiotic and chlorhexidine mouthrinses on clinical inflammatory parameters of gingivitis: A randomized controlled clinical study

The aim of our clinical trial was to assess and compare the antiplaque and anti-inflammatory potential of a probiotic mouthwash with 0.2% chlorhexidine and saline. A randomized parallel group study was designed for a period of 4 weeks on 45 systemically healthy subjects between 20 and 30 years havin...

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Bibliographic Details
Published in:Journal of Indian Society of Periodontology 2015-11, Vol.19 (6), p.633-639
Main Authors: Nadkerny, Purnima Vidyesh, Ravishankar, Potluri Leela, Pramod, Virupapuram, Agarwal, Lavanya Abhay, Bhandari, Saurabh
Format: Article
Language:English
Subjects:
Antibiotics
Care and treatment
Chlorhexidine
Comparative analysis
Dental research
Disease
Gingivitis
mouthrinse
Original
Patient outcomes
probiotic
Probiotics
Studies
Teeth
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Summary:The aim of our clinical trial was to assess and compare the antiplaque and anti-inflammatory potential of a probiotic mouthwash with 0.2% chlorhexidine and saline. A randomized parallel group study was designed for a period of 4 weeks on 45 systemically healthy subjects between 20 and 30 years having chronic gingivitis. The study population was divided into three groups. Group A - 15 subjects were advised experimental (probiotic) mouthwash. Group B - 15 subjects were advised positive control (chlorhexidine) mouthwash and Group C - 15 subjects into a negative control group (normal saline). Oral prophylaxis was done for all groups at baseline. After the proper oral hygiene instructions, all the three groups were instructed to rinse their mouth with 10 ml of their respective mouthrinse, undiluted for 1 min twice daily, 30 min after brushing. Clinical parameters such as plaque index (PI), gingival index (GI), and oral hygiene index simplified (OHI-S) were assessed at baseline, 2 weeks and 4 weeks, respectively. At day 28, the PI, GI, and OHI-S were significantly reduced by all treatment modalities ranking probiotic and chlorhexidine is greater than saline. The probiotic mouthrinses tested was effectively used as an adjunct to mechanical plaque control in the prevention of plaque and gingivitis. Thus, the probiotic mouthrinse has a great therapeutic potential.
ISSN:0972-124X
0975-1580
DOI:10.4103/0972-124X.168491