Novel pyridine and pyrimidine derivatives as promising anticancer agents: A review

[Display omitted] Pyridines and pyrimidines are the class of heterocyclic nitrogenous compounds having plethora of applications in anticancer drug development. These synthetic sources serve as the potent class of compounds in treatment of breast cancer, myeloid leukemia, pancreatic cancer, liver can...

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Bibliographic Details
Published in:Arabian journal of chemistry 2022-06, Vol.15 (6), p.103846, Article 103846
Main Authors: Albratty, Mohammed, Alhazmi, Hassan Ahmad
Format: Article
Language:English
Subjects:
Anticancer
Drugs
In silico
In vitro
Pyridine
Pyrimidine
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Summary:[Display omitted] Pyridines and pyrimidines are the class of heterocyclic nitrogenous compounds having plethora of applications in anticancer drug development. These synthetic sources serve as the potent class of compounds in treatment of breast cancer, myeloid leukemia, pancreatic cancer, liver cancer and idiopathic respiratory fibrosis etc. The present review enumerates the results of studies published during past three years (2019–2021) on pyridine and pyrimidine analogues with their respective anticancer properties characterized in vitro or through in silico studies and illustrates their potential in development of anticancer agents. Recent advances on pyridine and pyrimidine analogues mentioned in this review add to the appealing opportunities for cancer therapy.
ISSN:1878-5352
1878-5379
DOI:10.1016/j.arabjc.2022.103846