Immune Thrombocytopenia in a Child with Neuroblastoma

Thrombocytopenia is a frequent finding in patients with solid tumors. It is usually caused by bone marrow infiltration or by myelosuppression due to anticancer therapy; however immune thrombocytopenia (ITP) associated with solid tumors is rare. Neuroblastoma is the most common extracranial solid tum...

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Bibliographic Details
Published in:Case reports in pediatrics 2017-01, Vol.2017 (2017), p.1-4
Main Authors: Tecimer, Tulay, Tokat, Fatma, Ayan, Inci, Ikizoglu, Hasan Tarkan, Topuzlu Tekant, Gonca
Format: Article
Language:English
Subjects:
Abdomen
Antimitotic agents
Antineoplastic agents
Blood
Blood platelets
Bone marrow
Cancer therapies
Care and treatment
Case Report
Case reports
Children
Complications and side effects
Diagnosis
Dosage and administration
Family medical history
Health aspects
Hematology
Hepatitis
Hospitals
Leukemia
Lymphoma
Magnetic resonance imaging
Metastasis
Myelosuppression
Neuroblastoma
Oncology
Patients
Pediatrics
Radiation therapy
Substance abuse treatment
Surgery
Thrombocytopenic purpura
Tumors
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Summary:Thrombocytopenia is a frequent finding in patients with solid tumors. It is usually caused by bone marrow infiltration or by myelosuppression due to anticancer therapy; however immune thrombocytopenia (ITP) associated with solid tumors is rare. Neuroblastoma is the most common extracranial solid tumor in children. Here we report the case of a two-year-nine-month-old patient with adrenal neuroblastoma who presented with ITP. Paraneoplastic ITP was considered in the differential diagnosis. Bone marrow infiltration and other causes of thrombocytopenia were excluded and the patient was treated with intravenous immunoglobulin and tumor resection. Platelet count increased rapidly after surgery and complete remission of ITP was achieved.
ISSN:2090-6803
2090-6811
DOI:10.1155/2017/1329489