In Vivo Quantitative Ultrasound Image Analysis of Femoral Subchondral Bone in Knee Osteoarthritis

A potential of quantitative noninvasive knee ultrasonography (US) for detecting changes in femoral subchondral bone related to knee osteoarthritis (OA) was investigated. Thirty-nine patients referred to a knee arthroscopy underwent dynamic noninvasive US examination of the knee joint. The subchondra...

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Bibliographic Details
Published in:TheScientificWorld 2013-01, Vol.2013 (2013), p.1-8
Main Authors: Saarakkala, Simo, Pulkkinen, Pasi, Koski, Juhani M., Podlipská, Jana
Format: Article
Language:English
Subjects:
Acoustics
Adult
Aged
Algorithms
Arthritis
Arthroscopy
Biocompatibility
Biomedical materials
Cartilage
Cartilage diseases
Change detection
Clinical Study
Diagnosis
Disease
Evaluation
Feasibility studies
Female
Femur
Femur - diagnostic imaging
Grading
Humans
Image analysis
Image Interpretation, Computer-Assisted - methods
Image processing
Injuries
Joint surgery
Knee
Male
Mathematical analysis
Medical imaging
Methods
Middle Aged
Osteoarthritis
Osteoarthritis, Knee - diagnostic imaging
Physics
Reproducibility of Results
Sensitivity and Specificity
Statistical analysis
Subchondral bone
Ultrasonic imaging
Ultrasonography - methods
Ultrasound
Ultrasound imaging
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Summary:A potential of quantitative noninvasive knee ultrasonography (US) for detecting changes in femoral subchondral bone related to knee osteoarthritis (OA) was investigated. Thirty-nine patients referred to a knee arthroscopy underwent dynamic noninvasive US examination of the knee joint. The subchondral bone was semiautomatically segmented from representative US images of femoral medial and lateral condyles and intercondylar notch area. Subsequently, the normalized mean gray-level intensity profile, starting from the cartilage-bone interface and extending to the subchondral bone depth of ~1.7 mm, was calculated. The obtained profile was divided into 5 depth levels and the mean of each level, as well as the slope of the profile within the first two levels, was calculated. The US quantitative data were compared with the arthroscopic Noyes’ grading and radiographic Kellgren-Lawrence (K-L) grading. Qualitatively, an increase in relative subchondral bone US gray-level values was observed as OA progressed. Statistically significant correlations were observed between normalized US mean intensity or intensity slope especially in subchondral bone depth level 2 and K-L grading (r=0.600, P
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1155/2013/182562