Grb7, a Critical Mediator of EGFR/ErbB Signaling, in Cancer Development and as a Potential Therapeutic Target

The partner of activated epidermal growth factor receptor (EGFR), growth factor receptor bound protein-7 (Grb7), a functionally multidomain adaptor protein, has been demonstrated to be a pivotal regulator for varied physiological and pathological processes by interacting with phospho-tyrosine-relate...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2019-05, Vol.8 (5), p.435
Main Authors: Chu, Pei-Yu, Tai, Yu-Ling, Shen, Tang-Long
Format: Article
Language:English
Subjects:
Amino acids
Biomarkers, Tumor - chemistry
Biomarkers, Tumor - metabolism
Biomarkers, Tumor - physiology
Breast cancer
Cancer
cancer development
Cell adhesion & migration
Clinical aspects
Clinical trials
Epidermal growth factor
epidermal growth factor receptor
Epidermal growth factor receptors
ERBB family
ErbB protein
ErbB Receptors - metabolism
Esophageal cancer
Gene amplification
GRB7 Adaptor Protein - chemistry
GRB7 Adaptor Protein - metabolism
GRB7 Adaptor Protein - physiology
growth factor receptor bound protein-7
Growth factors
Humans
Insulin
Kinases
Malignancy
Nematodes
Neoplasms - metabolism
Neoplasms - therapy
Ovarian cancer
Peptide inhibitors
Phosphorylation
Physiology
prognostic marker
Proteins
Regulation
Review
Signal Transduction
Therapeutic applications
therapeutic target
Tyrosine
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Summary:The partner of activated epidermal growth factor receptor (EGFR), growth factor receptor bound protein-7 (Grb7), a functionally multidomain adaptor protein, has been demonstrated to be a pivotal regulator for varied physiological and pathological processes by interacting with phospho-tyrosine-related signaling molecules to affect the transmission through a number of signaling pathways. In particular, critical roles of Grb7 in erythroblastic leukemia viral oncogene homolog (ERBB) family-mediated cancer development and malignancy have been intensively evaluated. The overexpression of Grb7 or the coamplification/cooverexpression of Grb7 and members of the ERBB family play essential roles in advanced human cancers and are associated with decreased survival and recurrence of cancers, emphasizing Grb7's value as a prognostic marker and a therapeutic target. Peptide inhibitors of Grb7 are being tested in preclinical trials for their possible therapeutic effects. Here, we review the molecular, functional, and clinical aspects of Grb7 in ERBB family-mediated cancer development and malignancy with the aim to reveal alternative and effective therapeutic strategies.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells8050435