A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression

Minichromosome Maintenance Complex Component 3 Associated Protein Antisense 1 ( MCM3AP-AS1 ) is an RNA gene located on 21q22.3. The sense transcript from this locus has dual roles in the pathogenesis of solid tumors and hematological malignancies. MCM3AP-AS1 has been shown to sequester miR-194-5p, m...

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Bibliographic Details
Published in:Cancer cell international 2022-07, Vol.22 (1), p.1-14, Article 225
Main Authors: Ghafouri-Fard, Soudeh, Khoshbakht, Tayyebeh, Hussen, Bashdar Mahmud, Taheri, Mohammad, Samadian, Mohammad
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Apoptosis
Breast cancer
Cancer
Carcinogenesis
Cell cycle
Cervical cancer
Cervix
Chromosome 21
Colorectal cancer
Gastric cancer
Gene expression
Hematology
Kidney cancer
lncRNA
Lymphoma
MCM3AP-AS1
Non-coding RNA
Prostate cancer
Proteins
PTEN protein
Review
Roles
Signal transduction
Solid tumors
Thyroid cancer
Tumor suppressor genes
Tumors
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Summary:Minichromosome Maintenance Complex Component 3 Associated Protein Antisense 1 ( MCM3AP-AS1 ) is an RNA gene located on 21q22.3. The sense transcript from this locus has dual roles in the pathogenesis of solid tumors and hematological malignancies. MCM3AP-AS1 has been shown to sequester miR-194-5p, miR-876-5p, miR-543-3p, miR-28-5p, miR-93, miR-545, miR-599, miR‐193a‐5p, miR-363-5p, miR-204-5p, miR-211-5p, miR-15a, miR-708-5p, miR-138, miR-138-5p, miR-34a, miR-211, miR‐340‐5p, miR-148a, miR-195-5p and miR-126. Some cancer-related signaling pathway, namely PTEN/AKT, PI3K/AKT and ERK1/2 are influenced by this lncRNA. Cell line studies, animal studies and clinical studies have consistently reported oncogenic role of MCM3AP-AS1 in different tissues except for cervical cancer in which this lncRNA has tumor suppressor role. In the current manuscript, we collected evidence from these three sources of evidence to review the impact of MCM3AP-AS1 in the carcinogenesis.
ISSN:1475-2867
1475-2867
DOI:10.1186/s12935-022-02644-5