Favorable Effects of Virgin Coconut Oil on Neuronal Damage and Mortality after a Stroke Incidence in the Stroke-Prone Spontaneously Hypertensive Rat

Stroke is consistently one of the top ten causes of morbidity and mortality globally, whose outcomes are quite variable, necessitating case-specific management. Prophylactic diets before the onset of stroke have been implicated to work. In this research, the effects of virgin coconut oil (VCO) on st...

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Published in:Life (Basel, Switzerland) Switzerland), 2022-11, Vol.12 (11), p.1857
Main Authors: Vitor, 2nd, Rodel Jonathan Santos, Tochinai, Ryota, Sekizawa, Shin-Ichi, Kuwahara, Masayoshi
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
Blood pressure
Brain
Brain damage
Care and treatment
Coconut oil
Complications and side effects
Evaluation
Health aspects
Heart
Histopathology
Hypertension
Hypoxia
Ischemia
Morbidity
Mortality
Necropsy
neuronal damage
Neurons
Oral administration
Pathogenesis
Prevention
SHRSP model
Sodium chloride
Stroke
Stroke (Disease)
Survival
survival rate
Testing
virgin coconut oil
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Summary:Stroke is consistently one of the top ten causes of morbidity and mortality globally, whose outcomes are quite variable, necessitating case-specific management. Prophylactic diets before the onset of stroke have been implicated to work. In this research, the effects of virgin coconut oil (VCO) on stroke were evaluated using a stroke-prone spontaneously hypertensive rat (SHRSP) model. Eight-week-old SHRSPs were subjected to the repeated oral administration (5 mL/kg/day) of either 1% Tween 80 (group A) or VCO (group B). An early stroke onset was observed due to hypertension that was aggravation by the administration of 1% NaCl in water ad libitum. The following data were collected: the days until stroke occurred, the survival rate until the animal died, and blood pressure (BP) every two weeks using the tail-cuff method. After necropsy, the organs were harvested, and the brain was processed for a routine histopathological analysis. VCO delayed the incidence of it and prolonged their survival. Compared to group A, group B showed a significantly lowered BP by 20 mmHg at four weeks after the start of VCO treatment. Lastly, the brain histopathology showed that the structurally damaged areas were smaller in group B than they were in group A. The VCO could have protective effects on the brain before and even after stroke incidence.
ISSN:2075-1729
2075-1729
DOI:10.3390/life12111857