Control Theory and Systems Biology: Potential Applications in Neurodegeneration and Search for Therapeutic Targets

Control theory, a well-established discipline in engineering and mathematics, has found novel applications in systems biology. This interdisciplinary approach leverages the principles of feedback control and regulation to gain insights into the complex dynamics of cellular and molecular networks und...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-12, Vol.25 (1), p.365
Main Authors: Angarita-Rodríguez, Andrea, González-Giraldo, Yeimy, Rubio-Mesa, Juan J, Aristizábal, Andrés Felipe, Pinzón, Andrés, González, Janneth
Format: Article
Language:English
Subjects:
Biology
Chronic diseases
Chronic illnesses
Control systems
Control theory
Disease
Drug development
Genes
genome-scale metabolic networks
Genomes
Genotype & phenotype
Health aspects
Linear programming
Metabolism
Molecular dynamics
Neurodegeneration
neurodegenerative diseases
Optimization techniques
Review
systems biology
Technology application
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Summary:Control theory, a well-established discipline in engineering and mathematics, has found novel applications in systems biology. This interdisciplinary approach leverages the principles of feedback control and regulation to gain insights into the complex dynamics of cellular and molecular networks underlying chronic diseases, including neurodegeneration. By modeling and analyzing these intricate systems, control theory provides a framework to understand the pathophysiology and identify potential therapeutic targets. Therefore, this review examines the most widely used control methods in conjunction with genomic-scale metabolic models in the steady state of the multi-omics type. According to our research, this approach involves integrating experimental data, mathematical modeling, and computational analyses to simulate and control complex biological systems. In this review, we find that the most significant application of this methodology is associated with cancer, leaving a lack of knowledge in neurodegenerative models. However, this methodology, mainly associated with the Minimal Dominant Set (MDS), has provided a starting point for identifying therapeutic targets for drug development and personalized treatment strategies, paving the way for more effective therapies.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25010365