The Role of L-Carnitine in Kidney Disease and Related Metabolic Dysfunctions

Kidney disease is associated with a wide variety of metabolic abnormalities that accompany the uremic state and the state of dialysis dependence. These include altered L-carnitine homeostasis, mitochondrial dysfunctions, and abnormalities in fatty acid metabolism. L-carnitine is essential for fatty...

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Bibliographic Details
Published in:Kidney and dialysis 2023-06, Vol.3 (2), p.178-191
Main Authors: Ulinski, Tim, Cirulli, Maria, Virmani, Mohamed Ashraf
Format: Article
Language:English
Subjects:
acute kidney disease
anemia
erythropoietin
intradialytic hypotension
L-carnitine
mitochondria
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Summary:Kidney disease is associated with a wide variety of metabolic abnormalities that accompany the uremic state and the state of dialysis dependence. These include altered L-carnitine homeostasis, mitochondrial dysfunctions, and abnormalities in fatty acid metabolism. L-carnitine is essential for fatty acid metabolism and proper mitochondrial function. Deficiency in kidney disease and dialysis is caused by a reduction in endogenous renal synthesis, impaired fatty acid metabolism, a lower intake due to dietary restrictions, and nonselective clearance by the dialysis procedure. Free carnitine levels
ISSN:2673-8236
2673-8236
DOI:10.3390/kidneydial3020016