Metastatic Grade II simple tubulopapillary mammary carcinoma in a free-living female maned wolf (Chrysocyon brachyurus)

This study described the pathological aspects of a metastatic grade II simple tubulopapillary mammary carcinoma in a free-living senile female maned wolf (Chrysocyon brachyurus). The diagnosis was based on histopathological findings of malignant epithelial cells arranged in tubular and papillary pat...

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Bibliographic Details
Published in:Ciência rural 2024-01, Vol.54 (5)
Main Authors: Oliveira Junior, Ivam Moreira de, Reis, Matheus de Oliveira, Preta, Carolina de Oliveira Cata, Nunes, Maíra Meira, Ferreira, Daiane da Cruz, Abdalla, Daniella Corrêa, Favoretto, Samantha Mesquita, Varaschin, Mary Suzan
Format: Article
Language:English
Subjects:
AGRONOMY
Chrysocyon brachyurus
tubulopapillary mammary carcinoma
wild animals
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Summary:This study described the pathological aspects of a metastatic grade II simple tubulopapillary mammary carcinoma in a free-living senile female maned wolf (Chrysocyon brachyurus). The diagnosis was based on histopathological findings of malignant epithelial cells arranged in tubular and papillary patterns, with marked anisocytosis and anisokaryosis and metastases to regional lymph nodes, lungs, parietal pleura, and pericardium. Also associated to positive immunolabeling of neoplastic cells for Cytokeratin AE1/AE3 and negative for P63, Calponin and Cox-2, added to the cell proliferation index of 26.8%. The findings demonstrated that free-ranging wild canids develop mammary neoplasms similar to those observed in domestic canids. RESUMO: Este estudo descreve os aspectos patológicos de um carcinoma mamário simples túbulo-papilar metastático grau II em um lobo-guará, fêmea, senil de vida livre. O diagnóstico foi baseado nos achados histopatológicos de células malignas epiteliais arranjadas em um padrão tubular e papilar, com acentuada anisocitose e anisocariose e metástases para os linfonodos regionais, pulmão, pleura parietal e pericárdio. Também associado a marcação imuno-histoquímica positiva das células neoplásicas para Citoqueratina AE1/AE3 e negativas para P63, Calponina e Cox-2, somado ao índice de proliferação celular de 26,8%. Os achados demonstram que canídeos silvestres de vida livre podem desenvolver neoplasias mamárias similares às observadas em canídeos domésticos.
ISSN:0103-8478
1678-4596
1678-4596
DOI:10.1590/0103-8478cr20230063