Coupling AFM, DSC and FT-IR towards Elucidation of Film-Forming Systems Transformation to Dermal Films: A Betamethasone Dipropionate Case Study

Polymeric film-forming systems have emerged as an esthetically acceptable option for targeted, less frequent and controlled dermal drug delivery. However, their dynamic nature (rapid evaporation of solvents leading to the formation of thin films) presents a true characterization challenge. In this s...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-05, Vol.23 (11), p.6013
Main Authors: Timotijević, Mirjana D, Ilić, Tanja, Marković, Bojan, Randjelović, Danijela, Cekić, Nebojša, Nikolić, Ines, Savić, Snežana, Pantelić, Ivana
Format: Article
Language:English
Subjects:
Atomic force microscopy
Cellulose
Complementarity
Drug delivery
Drug delivery systems
Drug dosages
Evaporation
Film thickness
Fourier transforms
hydrophobic polymethacrylate copolymers
Hydrophobicity
Hydroxypropyl cellulose
lipophilic drug
Mechanical properties
Patient compliance
Pharmaceuticals
Phase transitions
Polymers
porcine ear epidermis
Product quality
Psoriasis
Skin
Surface roughness
Thermal analysis
Thin films
Transdermal medication
Viscosity
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Summary:Polymeric film-forming systems have emerged as an esthetically acceptable option for targeted, less frequent and controlled dermal drug delivery. However, their dynamic nature (rapid evaporation of solvents leading to the formation of thin films) presents a true characterization challenge. In this study, we tested a tiered characterization approach, leading to more efficient definition of the quality target product profiles of film-forming systems. After assessing a number of physico-chemico-mechanical properties, thermal, spectroscopic and microscopic techniques were introduced. Final confirmation of betamethasone dipropionate-loaded FFS biopharmaceutical properties was sought via an in vitro skin permeation study. A number of applied characterization methods showed complementarity. The sample based on a combination of hydrophobic Eudragit RS PO and hydroxypropyl cellulose showed higher viscosity (47.17 ± 3.06 mPa·s) and film thickness, resulting in sustained skin permeation (permeation rate of 0.348 ± 0.157 ng/cm h), and even the pH of the sample with Eudragit NE 30D, along with higher surface roughness and thermal analysis, implied its immediate delivery through the epidermal membrane. Therefore, this study revealed the utility of several methods able to refine the number of needed tests within the final product profile.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23116013