Establishment of prognostic model of bladder cancer based on apoptosis-related genes, in which P4HB promotes BLCA progression

Background A variety of apoptosis genes have been confirmed to be related to the occurrence and development of bladder cancer patients, but few studies have paid attention to their significance in the prognosis of bladder cancer. Therefore, this study explored the value of apoptosis-related genes in...

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Bibliographic Details
Published in:BMC urology 2023-10, Vol.23 (1), p.1-167, Article 167
Main Authors: Zou, Zhenhai, Li, Zhong, Sun, Wei, Gao, Wuyue, Liu, Beibei, Liu, Jianmin, Guo, Yuanyuan
Format: Article
Language:English
Subjects:
Analysis
Apoptosis
Apoptosis-related genes
Bladder cancer
Bladder carcinoma
Cancer
Cancer patients
Cancer therapies
Cell death
Chemotherapy
Correlation analysis
Gene expression
Genes
Genetic aspects
Genomes
Immune checkpoint
Immune infiltration
Immune response
Medical prognosis
Medical research
Medicine, Experimental
Metastasis
MicroRNAs
Nomograms
P4HB
Prognosis
Prognostic model
Regression analysis
Risk groups
RNA
Software
Urology
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Summary:Background A variety of apoptosis genes have been confirmed to be related to the occurrence and development of bladder cancer patients, but few studies have paid attention to their significance in the prognosis of bladder cancer. Therefore, this study explored the value of apoptosis-related genes in the prognosis of BLCA by using the data in TCGA database. Methods We downloaded the mRNA expression profiles and corresponding clinical data of bladder cancer patients from TCGA database, and obtained 2411 apoptosis-related genes from Deathbase database. Screening out differentially expressed apoptosis-related genes. Cox regression was used to determine the prognostic value of apoptosis-related genes, and then a prognostic risk model was developed. A nomogram based on risk model was constructed to predict the prognosis of bladder cancer patients. At the same time, immune infiltration correlation analysis of genes in the prognosis model. Results A prognostic model composed of 12 apoptosis-related genes was constructed. According to the risk score calculated by the model, patients were divided into high-risk group and low-risk group. There are significant differences in the expression of immune cells, immune function and immune checkpoint molecules between high-risk group and low-risk group. P4HB may promote bladder cancer progression. Conclusion Based on the differential expression of apoptosis-related genes, we established a risk model to predict the prognosis of bladder cancer patients, in which P4HB promotes BLCA progression. Keywords: Apoptosis-related genes, Bladder carcinoma, Prognostic model, Immune infiltration, P4HB
ISSN:1471-2490
1471-2490
DOI:10.1186/s12894-023-01331-5