T Cell Dysregulation in Non-silicotic Silica Exposed Workers: A Step Toward Immune Tolerance Breakdown

Chronic silica exposure can lead to silicosis, complicated or not by autoimmune diseases (AID). The pathophysiology of silica-induced AID remains not fully understood, especially immune mechanisms that may develop in patients without yet established silicosis. We conducted a prospective clinical stu...

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Bibliographic Details
Published in:Frontiers in immunology 2019-11, Vol.10, p.2743-2743
Main Authors: Brilland, Benoit, Beauvillain, Céline, Mazurkiewicz, Gery, Rucay, Pierre, Roquelaure, Yves, Tabiasco, Julie, Vinatier, Emeline, Riou, Jérémie, Jeannin, Pascale, Renier, Gilles, Subra, Jean-François, Augusto, Jean-François
Format: Article
Language:English
Subjects:
activated T cells
auto-antibodies
auto-immune diseases
crystalline silica
Immunology
Life Sciences
occupational diseases
regulatory T cells
Santé publique et épidémiologie
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Summary:Chronic silica exposure can lead to silicosis, complicated or not by autoimmune diseases (AID). The pathophysiology of silica-induced AID remains not fully understood, especially immune mechanisms that may develop in patients without yet established silicosis. We conducted a prospective clinical study to analyze the impact of crystalline silica (CS) on T cell phenotype and regulatory T cells (Tregs) frequency, as well as on auto-antibodies development in non-silicotic workers exposed to CS. Workers with moderate to high exposure level to CS and aged between 30 and 60 years-old were considered for inclusion. Peripheral blood mononuclear cells were analyzed by flow cytometry. Auto-antibodies were screened in serum by immunofluorescence. Blood from 42 and 45 healthy subjects (HC) was used as control for T cell phenotype and serum analyses, respectively. Among the 63 included workers exposed to CS, 55 had full data available and were analyzed. Ten were exposed to CS for
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2019.02743