Prognostic value of early radiological response to first‐line platinum‐containing chemotherapy in patients with metastatic nasopharyngeal carcinoma

Background To explore the prognostic value of early radiological response (ERR) to first‐line platinum‐containing chemotherapy in patients with metastatic nasopharyngeal carcinoma (mNPC), as well as its correlation with the best radiological response (BRR). Patients and methods A total of 756 mNPC p...

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Bibliographic Details
Published in:Cancer medicine (Malden, MA) MA), 2020-02, Vol.9 (3), p.920-930
Main Authors: Liu, Guo‐Ying, Li, Wang‐Zhong, Peng, Kang‐Qiang, Lv, Xing, Ke, Liang‐Ru, Wu, Yi‐Shan, Wang, De‐Ling, Liang, Hu, Liu, Kui‐Yuan, Lv, Shu‐Hui, Guo, Xiang, Xiang, Yan‐Qun, Xia, Wei‐Xiong
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cancer therapies
Chemotherapy
Cisplatin - therapeutic use
Clinical Cancer Research
Disease
early radiological response
Female
first‐line chemotherapy
Follow-Up Studies
Histology
Humans
Kaplan-Meier Estimate
Magnetic Resonance Imaging
Male
Medical prognosis
Metastases
Metastasis
metastatic nasopharyngeal carcinoma
Middle Aged
Nasopharyngeal carcinoma
Nasopharyngeal Carcinoma - drug therapy
Nasopharyngeal Carcinoma - mortality
Nasopharyngeal Carcinoma - secondary
Nasopharyngeal Neoplasms - diagnosis
Nasopharyngeal Neoplasms - drug therapy
Nasopharyngeal Neoplasms - mortality
Nasopharyngeal Neoplasms - pathology
Nasopharynx - diagnostic imaging
Nasopharynx - pathology
Original Research
Patients
Platinum
Prognosis
Progression-Free Survival
Prospective Studies
Radionuclide Imaging
Response Evaluation Criteria in Solid Tumors
Retrospective Studies
Solid tumors
Statistical analysis
Survival
Survival Rate
Throat cancer
Tomography, X-Ray Computed
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Summary:Background To explore the prognostic value of early radiological response (ERR) to first‐line platinum‐containing chemotherapy in patients with metastatic nasopharyngeal carcinoma (mNPC), as well as its correlation with the best radiological response (BRR). Patients and methods A total of 756 mNPC patients with measurable lesions who received first‐line platinum‐containing chemotherapy were enrolled in this study. ERR was defined as complete or partial response after 6 weeks of chemotherapy according to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. We performed survival analyses according to the radiological response after repeated chemotherapy. Log‐rank test and Cox regression were used to analyze the survival data. Results About 470 patients achieved ERR and 78 patients achieved subsequent response (objective response after repeated chemotherapy). ERR patients had better OS (P 
ISSN:2045-7634
2045-7634
DOI:10.1002/cam4.2751