Hyperprolactinemia and insulin resistance in drug naive patients with early onset first episode psychosis

Hyperprolactinemia and glucose and lipid metabolism abnormalities are often found in patients with schizophrenia and are generally considered secondary to the use of antipsychotic drugs. More recent studies have shown these same neuroendocrine and metabolic abnormalities in antipsychotic naïve patie...

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Bibliographic Details
Published in:BMC psychiatry 2018-08, Vol.18 (1), p.246-246, Article 246
Main Authors: Petruzzelli, Maria Giuseppina, Margari, Mariella, Peschechera, Antonia, de Giambattista, Concetta, De Giacomo, Andrea, Matera, Emilia, Margari, Francesco
Format: Article
Language:English
Subjects:
Adolescence
Analysis
Antipsychotic agents
Antipsychotics
Blood glucose
Child development
Clinical high risk of psychosis
Complications and side effects
Diabetes
Dopamine
Dosage and administration
Drug therapy
Glucose
Glucose tolerance
Homeostasis
Hyperprolactinemia
Hypotheses
Insulin
Insulin resistance
Lipids
Metabolic syndrome
Neuroendocrine dysfunctions
Patient outcomes
Pediatrics
Physiological aspects
Prolactin regulation
Psychiatry
Psychosis
Psychotic disorders
Psychotropic drugs
Risk factors
Schizophrenia
Schizophrenia spectrum psychosis
Teenagers
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Summary:Hyperprolactinemia and glucose and lipid metabolism abnormalities are often found in patients with schizophrenia and are generally considered secondary to the use of antipsychotic drugs. More recent studies have shown these same neuroendocrine and metabolic abnormalities in antipsychotic naïve patients with first episode psychosis (FEP), rising the hypothesis that schizophrenia itself may be related to an abnormal regulation of prolactin secretion and to impaired glucose tolerance. The aim of this study was to compare prolactin levels, glycometabolism parameters and lipid profile between a sample of 31 drug-naive adolescents in the acute phase of FEP and a control group of 23 subjects at clinical high risk (CHR) of developing psychosis. The assessment involved anthropometric data (weight, height, BMI index, pubertal stage) and blood tests (levels of glucose, glycated hemoglobin, serum insulin, triglycerides, total and fractionated cholesterol, prolactin). Insulin resistance (IR) was calculated through the homeostatic model of assessment (HOMA-IR), assuming a cut-off point of 3.16 for adolescent population. FEP patients and CHR controls were compared by using Student's t-distribution (t-test) for parametric data. P 
ISSN:1471-244X
1471-244X
DOI:10.1186/s12888-018-1827-3