Alteration of cortical functional networks in mood disorders with resting-state electroencephalography

Studies comparing bipolar disorder (BD) and major depressive disorder (MDD) are scarce, and the neuropathology of these disorders is poorly understood. This study investigated source-level cortical functional networks using resting-state electroencephalography (EEG) in patients with BD and MDD. EEG...

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Published in:Scientific reports 2022-04, Vol.12 (1), p.5920-5920, Article 5920
Main Authors: Kim, Sungkean, Baek, Ji Hyun, Shim, Se-hoon, Kwon, Young Joon, Lee, Hwa Young, Yoo, Jae Hyun, Kim, Ji Sun
Format: Article
Language:English
Subjects:
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Bipolar disorder
Bipolar Disorder - diagnostic imaging
Bipolar Disorder - therapy
Brain - diagnostic imaging
Case-Control Studies
Cluster Analysis
Cortex (parietal)
Depressive Disorder, Major - diagnostic imaging
Depressive Disorder, Major - therapy
EEG
Electroencephalography
Electroencephalography - classification
Humanities and Social Sciences
Humans
Magnetic Resonance Imaging
Mental depression
Mood Disorders
multidisciplinary
Science
Science (multidisciplinary)
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Summary:Studies comparing bipolar disorder (BD) and major depressive disorder (MDD) are scarce, and the neuropathology of these disorders is poorly understood. This study investigated source-level cortical functional networks using resting-state electroencephalography (EEG) in patients with BD and MDD. EEG was recorded in 35 patients with BD, 39 patients with MDD, and 42 healthy controls (HCs). Graph theory-based source-level weighted functional networks were assessed via strength, clustering coefficient (CC), and path length (PL) in six frequency bands. At the global level, patients with BD and MDD showed higher strength and CC, and lower PL in the high beta band, compared to HCs. At the nodal level, compared to HCs, patients with BD showed higher high beta band nodal CCs in the right precuneus, left isthmus cingulate, bilateral paracentral, and left superior frontal; however, patients with MDD showed higher nodal CC only in the right precuneus compared to HCs. Although both MDD and BD patients had similar global level network changes, they had different nodal level network changes compared to HCs. Our findings might suggest more altered cortical functional network in patients with BD than in those with MDD.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-10038-w