White matter integrity in hospitalized COVID-19 patients is not associated with short- and long-term clinical outcomes

SARS-CoV-2 infection is associated with a decline in functional outcomes; many patients experience persistent symptoms, while the underlying pathophysiology remains unclear. This study investigated white matter (WM) integrity on brain MRI in hospitalized COVID-19 patients and its associations with c...

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Bibliographic Details
Published in:Frontiers in neurology 2024-08, Vol.15, p.1440294
Main Authors: van Lith, Theresa J, Li, Hao, van der Wijk, Marte W, Wijers, Naomi T, Sluis, Wouter M, Wermer, Marieke J H, de Leeuw, Frank-Erik, Meijer, Frederick J A, Tuladhar, Anil M
Format: Article
Language:English
Subjects:
COVID-19
DTI
DWI
MRI
Neurology
NODDI
white matter integrity
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Summary:SARS-CoV-2 infection is associated with a decline in functional outcomes; many patients experience persistent symptoms, while the underlying pathophysiology remains unclear. This study investigated white matter (WM) integrity on brain MRI in hospitalized COVID-19 patients and its associations with clinical outcomes, including long COVID. We included hospitalized COVID-19 patients and controls from CORONavirus and Ischemic Stroke (CORONIS), an observational cohort study, who underwent MRI-DWI imaging at baseline shortly after discharge (
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2024.1440294